针对冠状病毒炎症:针对新兴威胁的基于aptamer的策略
Yongyun Zhao1,2, Gang Yang1,2, Zhaoyong Zhang3
1Department of Respiratory and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital; Department Center for Functional Genomics and Bioinformatics, College of Life Science, Sichuan University, Chengdu, Sichuan, PR China.
Signal transduction and targeted therapy
|February 12, 2026
概括
一种新的DNA吸附体,NApt8-3,向保存的冠状病毒核体蛋白,抑制炎症. 一种联合疗法,circSASON,在小鼠中降低了SARS-CoV-2,显示出未来流行病治疗的潜力.
科学领域:
- 生物技术是生物技术.
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 冠状病毒对全球健康构成重大威胁,需要针对新兴变种制定新的治疗策略.
- 核体 (N) 蛋白质是多个冠状病毒的保存目标,涉及宿主炎症反应.
研究的目的:
- 为了设计一种针对保存的冠状病毒核体 (N) 蛋白的宽谱DNA吸收体.
- 开发和评估一种用于抑制冠状病毒复制和相关炎症的新型治疗剂.
主要方法:
- 设计了一种单链DNA吸附体 (NApt8-3),与各种冠状病毒的保存N蛋白结合.
- 开发了circSASON,这是一个结合NApt8-3,抗尖峰的阿普坦和针对N基因的反感性寡核化物 (ASO) 的嵌合体.
- 在实验室对SARS-CoV-2复制和细胞因子表达的有效性进行了评估,并在小鼠体内通过鼻腔注射对体内的治疗潜力进行了评估.
主要成果:
- NApt8-3选择性地结合N蛋白,通过阻断NLRP3炎症酶相互作用来抑制N蛋白诱导的炎症性细胞因子表达.
- 在实验室中,circSASON证明有效抑制了SARS-CoV-2复制,并抑制了N蛋白诱导的细胞因子产生.
- 在SARS-CoV-2感染的小鼠模型中,CircSASON的鼻内注射显著降低了病毒载量和缓解了肺炎.
结论:
- NApt8-3是一种强大的广谱抗炎剂,向保存的冠状病毒N蛋白.
- circSASON的治疗策略显示了对抗SARS-CoV-2和潜在的未来冠状病毒变体的前景.
- 这项研究为快速开发针对新出现的病毒威胁的基于aptamer的治疗方法提供了框架.
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