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Updated: Feb 14, 2026

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice
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A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Published on: May 15, 2019

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细胞启动因子4E:在不同年龄段的创伤性压力诱导抑郁相关的认知衰退的一个关键因素

Chi-Wei Lee1,2, Tzu-Jung Yang2, Ming-Chia Chu2

  • 1Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Translational psychiatry
|February 12, 2026
PubMed
概括

创伤性压力使老年小鼠的认知障碍和抑郁症恶化,与GABAergic系统和eIF4E酸化有关. 抑制eIF4E酸化改善了抑郁症和认知问题.

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