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Updated: May 5, 2026

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells
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结合姿势深度调节可光开关联体在5-HT2A受体的有效性

Verena Weber1,2, Giacomo Salvadori3, Federico Natale1,2

  • 1RWTH Aachen University, Aachen, Germany.

Communications chemistry
|February 12, 2026
PubMed
概括

预测光开关联体的有效性是很困难的. 在色胺5-HT2A受体结合口袋中插入连接体的深度,而不仅仅是结构,决定了受体激活和信号控制.

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