在全方位造血细胞移植受体中全面评估味觉功能障碍:综合主观和客观评估
Yoko Tsukamoto1,2, Saori Oku3, Junichi Yamazoe2
1Dental Hygiene Section, Department of Medical Technology, Kyushu University Hospital, Kyushu University, Fukuoka, Japan.
概括
味觉功能障碍在异质造血细胞移植 (allo-HCT) 后很常见,影响生活质量. 移植后客观味道值保持稳定,但主观味道改变得分恶化,表明复杂的潜在机制.
科学领域:
- 血液学 血液学 血液学
- 移植科学 移植科学
- 在瘤学瘤学.
背景情况:
- 味觉功能障碍是异性造血细胞移植 (allo-HCT) 接受者的未被认可的并发症.
- 这种功能障碍可能会对口服摄入量,营养状况和生活质量产生负面影响.
研究的目的:
- 通过客观和主观措施,全面评估alo-HCT接受者的味觉功能.
- 为了确定与移植后味觉障碍相关的临床因素.
主要方法:
- 一项前性观察性研究,涉及21名成年allo-HCT接受者.
- 使用全口味测试和化疗诱导的味道变化量表 (CiTAS) 评估了预调和预释的味道功能.
主要成果:
- 大多数患者在移植前有客观味觉功能障碍,特别是甜味,味,酸味和苦味.
- 移植后客观口味值保持稳定,但主观CITAS得分恶化.
- 一个趋势表明,胃肠移植与宿主疾病 (GI-GVHD) 患者的乌玛米口味得到了更好的保存.
结论:
- 主观和客观味觉评估之间存在差异,这表明味觉的多因素调节.
- 强化支持性护理可以通过心理安慰间接改善自我报告的味觉症状.
- 需要进一步的研究来探索像GI-GVHD这样的系统因素对乌玛米敏感性的影响.
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