在穆拉戈医院的威尔姆斯瘤儿童中,患病率和与延迟手术相关的因素:一种混合方法研究
Daniel Lule1, Shamim Nabidda2, Abraham Muhwezi3
1Department of Clinical Epidemiology and Biostatistics, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda. luledaniel71@gmail.com.
BMC cancer
|February 12, 2026
概括
维尔姆斯瘤 (WT) 的延迟手术影响了乌干达60%以上的儿童,与诊断年份,瘤因素和治疗有关. 解决系统和患者层面的障碍对于改善儿童癌症护理的生存率至关重要.
科学领域:
- 儿科瘤学 儿科瘤学
- 外科手术的结果
- 全球健康 全球健康
背景情况:
- 在高收入国家,威尔姆斯瘤 (WT) 的生存率很高 (>90%),但在低收入和中等收入国家,生存率仍然很低.
- 延迟手术是导致WT治疗结果不佳和复杂治疗的主要因素.
- 在乌干达,关于延迟WT手术的患病率和相关因素的数据有限.
研究的目的:
- 在乌干达穆拉戈医院确定WT儿童延迟手术的患病率.
- 确定与延迟WT手术干预相关的因素.
- 探索影响及时WT手术的障碍和促进因素.
主要方法:
- 采用了融合并发混合方法设计.
- 定量分析涉及261名患者记录的回顾性横截面研究,使用修改的波桑回归.
- 定性分析包括对10名医疗保健工作者和10名护理人员进行深入采访,并根据主题进行分析.
主要成果:
- 延迟WT手术的患病率为63.6%.
- 与延迟手术相关的因素包括诊断年份,瘤横向性,化疗后的血红蛋白水平和特定的化疗方案.
- 定性数据确定了系统性,患者级,化疗和瘤相关的障碍和促进因素.
结论:
- 在WT儿童中观察到延迟手术的高患病率.
- 手术延迟源于临床,系统和患者相关因素的复杂相互作用.
- 针对机构和患者层面的障碍的干预措施是必要的,以减少手术延迟和提高WT结果.
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