尿道真菌微生物组和与膀过活的关联,抗生素和治疗反应
Glenn T Werneburg1,2, Michael D Gross1, Daniel R Hettel1
1Department of Urology, Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Neurourology and urodynamics
|February 13, 2026
概括
尿道菌群在健康妇女和过度活跃膀 (OAB) 妇女之间有所不同. 菌在尿路微生物组内的复杂相互作用中发挥着关键作用.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 微生物学 微生物学
- 菌类学 菌类学是指菌类学.
背景情况:
- 尿路微生物组,包括真菌 (mycobiome),越来越多地被认为是其在健康和疾病中的作用.
- 过度活性膀 (OAB) 是一种影响生活质量的常见疾病,其潜在机制尚未完全理解.
研究的目的:
- 描述和比较有OAB和没有OAB的女性的尿路菌群.
- 调查真菌生物和OAB并发症,抗生素暴露和治疗反应之间的关联.
主要方法:
- 来自152名女性 (有和没有OAB) 的尿样使用内部转录间隔器 (ITS) 测序来识别真菌DNA进行了分析.
- 评估了真菌多样性,相对丰富性和王国间真菌-细菌相互作用.
主要成果:
- 在98%的样本中检测到真菌,其中Basidiomycota和Ascomycota是主要的类.
- 像Candida和Debaryomyces这样的特定属在OAB和健康群体之间显示出差异的丰度.
- 尿道菌群组成因OAB状态,糖尿病,抗生素使用和治疗结果而有所不同,突出显示了真菌在微生物群落中的中心作用.
结论:
- 这项研究揭示了OAB和没有OAB的女性的尿道真菌特征.
- 菌是尿路的王国间微生物网络的组成部分.
- 这些发现表明,在尿路菌群中,尿道疾病可能是治疗点.
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