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相关概念视频

Natural and Artificial Concepts01:24

Natural and Artificial Concepts

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In psychology, concepts can be divided into two categories: natural and artificial. Natural concepts are formed through direct or indirect experiences. For example, consider the concept of snow. If you live in a place with regular snowfall, such as Essex Junction, Vermont, you know snow through direct experiences. You’ve seen it fall, touched it, shoveled it, and played in it. You recognize its texture, appearance, and even its smell. In contrast, if you live on an island like Saint...
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Multipotency of Hematopoietic Stem Cells01:19

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Somatic to iPS Cell Reprogramming01:29

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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What is Natural Selection?01:32

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Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
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Nature and Nurture01:10

Nature and Nurture

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Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
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相关实验视频

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自然和人工的造血细胞重编程

Dong Yu1, Wenpei Liu1, Feng Liu1

  • 1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine (Shanghai), Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Cellular reprogramming
|February 13, 2026
PubMed
概括

造血细胞重编程将一种血液或免疫细胞转化为另一种血液或免疫细胞,为疾病理解和治疗提供了潜力. 技术的进步正在提高效率和临床使用,但仍然存在挑战.

关键词:
细胞重新编程的重编程造血细胞是造血细胞的组成部分.重编程诱导器的诱导器.瘤微环境是一个微环境.

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科学领域:

  • 血液学 血液学 血液学
  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 再生医学是一种再生医学.

背景情况:

  • 造血细胞重编程涉及将一种血液或免疫细胞类型转化为另一种.
  • 这一过程对于理解血液形成,疾病机制和开发新疗法至关重要.
  • 它通过转差异化,脱差异化或可塑性发生,受各种线索和压力因素的影响.

研究的目的:

  • 审查血造细胞重编程在促进血液学和免疫学的潜力.
  • 讨论细胞转化中的机制,挑战和新兴策略.
  • 突出个性化细胞疗法的未来前景.

主要方法:

  • 关于造血细胞重编程的当前文献的综述.
  • 分析多组学,基因编辑和化学生物学方面的进展.
  • 整合人工智能和单细胞分析,用于协议开发.

主要成果:

  • 造血细胞重编程对于理解血细胞发育和免疫系统疾病具有变革的潜力.
  • 技术进步正在提高重编程的有效性和临床可翻译性.
  • 挑战包括低效率,表型不稳定性和安全问题.

结论:

  • 造血细胞重编程为瘤学,免疫学和再生医学中的个性化细胞疗法提供了有希望的途径.
  • 克服交付,特异性和长期疗效方面的挑战是临床实现的关键.
  • 集成尖端技术对于未来的进步至关重要.