相关实验视频
Updated: Feb 14, 2026

16:00
Behavioral Assessment of Manual Dexterity in Non-Human Primates
Published on: November 11, 2011
23.1K
在怀孕的非人类灵长类模型的长度研究中采用胆病样本的应用
Sarah N Cilvik1, Michelle N Sullivan2, Theodore R Hobbs2
1Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.
Animals : an open access journal from MDPI
|February 13, 2026
概括
使用超声波导向针吸收的 rhesus macaque 胎盘活检为怀孕研究提供了宝贵的纵向数据. 这种新方法方法 (NAM) 改善了动物福利,并减少了手术分娩的需要.
科学领域:
- 生殖生物学 生殖生物学
- 动物模型动物模型
- 生物技术是生物技术.
背景情况:
- 由于生理上的相似之处, rhesus macaques 是人类怀孕研究的重要模型.
- 之前的研究采用了非侵入性成像和分娩后组织分析.
- 扩大对正在进行的怀孕的纵向数据的访问是至关重要的.
研究的目的:
- 开发和验证在 rhesus 中进行胎盘活检的超声导针吸收.
- 为程序培训建立一个胆皮取样 (CVS) 模拟模型.
- 评估在怀孕研究中使用新方法 (NAM) 进行连续活检的可行性.
主要方法:
- 开发了一种用于培训的胆 ?? 囊采样 (CVS) 模拟模型.
- 在三只 rhesus 身上进行了超声波引导的针吸收用于胎盘活检.
- 在妊娠40至106天之间连续采集样本.
主要成果:
- 活检样本产生了足够的组织用于组织学,RNA分析和热囊细胞有机体隔离.
- 从吸入样本中获得良好的RNA质量和产量.
- 在连续的CVS程序后,没有发生自发的早产.
结论:
- 超声导向的胎盘活检是对 rhesus macaques 进行纵向研究的可行方法.
- 这种新方法方法 (NAM) 提高了动物福利,并减少了动物数量.
- 通过减少手术分娩的需要,使早期怀孕研究取得进展.
相关概念视频
Longitudinal Studies
537
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
537
Longitudinal Research
13.5K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.5K
Typical Model Studies
638
Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
638
Mouse Models of Cancer Study
6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K
Sampling Methods: Sample Types
3.3K
Sampling materials are classified into three main types: solid, liquid, and gas.
Solid samples include a variety of substances, such as sediments from water bodies, soil, metals, and biological tissues. Two standard methods for extracting sediments from water bodies are grab sampling and piston coring. Grab sampling involves using a device to collect a discrete sediment sample from the bottom of a water body with minimal disturbance. Grab samples do not always represent the entire area due to...
Solid samples include a variety of substances, such as sediments from water bodies, soil, metals, and biological tissues. Two standard methods for extracting sediments from water bodies are grab sampling and piston coring. Grab sampling involves using a device to collect a discrete sediment sample from the bottom of a water body with minimal disturbance. Grab samples do not always represent the entire area due to...
3.3K
Case Studies
13.7K
There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
13.7K

