用于母马子宫输液的抗生素制剂的表面pH稳定性
Mariana Polesso Mazzuchini1,2, Igor F Canisso1
1Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, IL 61802, USA.
Animals : an open access journal from MDPI
|February 13, 2026
概括
研究母马的子宫输液稳定性显示,pH值波动显著影响抗生素的有效性. 储存条件和载体溶液会影响pH值,这凸显了治疗子宫内膜炎的母马时需要进行质量控制的必要性.
科学领域:
- 兽医生源学 兽医生源学
- 马类繁殖 马类繁殖 马类繁殖
- 药理学 药理学是指药理学的学科.
背景情况:
- 传染性子宫内膜炎是马子不育的主要原因之一.
- 对于子宫内注射抗生素有确定的指导方针,但溶液的稳定性没有记录.
研究的目的:
- 为了研究普通马子宫输液制剂的pH稳定性.
- 评估储存温度,度,缓冲器和车载溶液对24小时稳定性的影响.
主要方法:
- 测试了8种抗生素在不同温度下的盐溶液和乳酸林格溶液中的pH稳定性.
- 评估了不同度和与生物膜破坏物的组合.
- 在24小时内在多个时间点监控解决方案.
主要成果:
- 储存条件和pH值波动显著影响了抗生素溶液的稳定性.
- 氨基糖化物溶液的pH值增加;其他溶液的pH值下降,尤其是在更高的温度下.
- 缓冲剂如二碳酸可能会提高某些抗生素的稳定性.
结论:
- 马子宫输液的pH稳定性是可变的,并受到储存和载体选择的影响.
- 对于用于马匹的抗生素治疗,质量控制至关重要.
- 需要进一步的研究来确定观察到的pH值变化对抗微生物活性的临床影响.
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