在接受多剂化疗的狗中观察到带中性粒细胞,包括温克里斯
Caitlin N Eliason1,2, Steven J Pierce3, Alison Masyr1
1Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
Animals : an open access journal from MDPI
|February 13, 2026
概括
在接受化疗的狗中记录了带中性粒细胞或带血症. 较小的身体表面积和某些化疗药物,如温克里斯和多克索鲁比,与增加的带血病患病率有关.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 在瘤学瘤学.
- 血液学 血液学 血液学
背景情况:
- 化疗通常会在狗中诱导中性衰竭.
- 左转,以带血症为特征,以前没有在接受化疗的狗中记录过.
研究的目的:
- 为了确定接受多剂化疗的狗中带中性粒细胞升高的患病率.
- 为了确定与这些狗的带血病发展相关的因素.
主要方法:
- 从2018-2022年对医疗记录的回顾性审查.
- 分析身体表面积,白细胞计数,细分和带状中性粒细胞计数,以及使用的化疗药物.
- 使用通用线性混合模型进行统计分析.
主要成果:
- 带中性粒细胞存在于20.2%的纳迪尔全血计数 (CBCs).
- 带中性粒细胞 (带血症) 的增加发生在13.6%的CBC中.
- 较小的身体表面积与更高的带血病患病率有关.
- 与环胺相比,克里斯或多克索鲁比辛的使用后,带血病的患病率更高.
结论:
- 带中性粒细胞存在于接受化疗的狗中.
- 带血病的患病率与身体表面积有负相关性.
- 芬克里斯和多克索鲁比的使用与更高的带血病患病率有关.
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