化补充剂对断奶小猪生长表现和肠道发育的剂量和时间依赖的影响
Min Wang1, Siqi Li1, Xin Wang1
1Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
饮食中化 (CoCl2) 补充剂改善了早期的断奶后小猪生长,减少了腹. 然而,长期或高剂量的CoCl2对生长和肠道发育产生了负面影响,这表明短期的低剂量使用是最优的.
科学领域:
- 动物科学动物科学
- 营养生物化学 营养生物化学
- 胃肠病学 胃肠病学
背景情况:
- 断奶后腹和生长迟缓是生猪生产中的重大挑战.
- 化 (CoCl2) 是一种潜在的营养补充剂,但它对断奶小猪的影响需要详细评估.
- 了解CoCl2对肠道发育和基因表达的影响对于优化其使用至关重要.
研究的目的:
- 调查饮食中化 (CoCl2) 补充剂对断奶后小猪腹,生长表现和肠道发育的影响.
- 为了确定对CoCl2补充剂的剂量和时间依赖的反应.
- 探索CoCl2对肠道基因表达的影响背后的分子机制.
主要方法:
- 26只断奶小猪被分配给控制,低剂量 (1毫克/公斤) 或高剂量 (2毫克/公斤) 的CoCl2饮食28天.
- 评估了生长表现,便分数和肠道形态 (维卢斯高度,密室深度).
- 分析了与营养物质运输,新陈代谢和信号通路相关的基因表达.
- 实验室肠道有机体模型被用于研究CoCl2对细胞分化和基因表达的影响.
主要成果:
- 早期的CoCl2补充 (14天) 显示了平均每日增益 (ADG) 和减少便得分的有利趋势.
- 较晚或较高剂量的CoCl2补充 (28天或2毫克/公斤) 负面影响了料摄入量和ADG.
- CoCl2诱导了肠道形态,杯细胞数量和肠内分泌细胞的剂量依赖性改变.
- 营养物质载体 (DMT1,GLUT2,SGLT1) 和与代谢相关的基因的基因表达与增加的CoCl2水平线性下降.
- 试验室研究表明,CoCl2减少了有机体的芽,并改变了SGLT1和CHGA基因表达.
结论:
- 食CoCl2补充剂在断奶后的小猪身上表现出剂量和时间依赖的影响.
- 短期 (14天),低剂量 (<2毫克/公斤) CoCl2 可能有助于早期断奶后的表现,并减少腹.
- 长期或高剂量的CoCl2补充剂可能会对小猪生长和肠道发育产生不利影响,需要谨慎.
更多相关视频
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
09:00Eye Removal in Living Zebrafish Larvae to Examine Innervation-dependent Growth and Development of the Visual System
Published on: February 11, 2022
相关概念视频
Drug Toxicity: Dose-Dependent Reactions
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Chronopharmacokinetics: Time-Dependent Pharmacokinetics
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
The Integrated Rate Law: The Dependence of Concentration on Time
Biological Effects of Radiation
