低蛋白P与腹腔透析中的周围动脉疾病独立相关
I-Min Su1,2,3, Chung-Jen Lee4, Chiu-Huang Kuo5,6
1Institute of Medical Science, Tzu Chi University, Hualien 97004, Taiwan.
Diagnostics (Basel, Switzerland)
|February 13, 2026
概括
低血清蛋白P (SePP) 水平与腹腔透析 (PD) 患者的外周动脉疾病 (PAD) 有关. 在这个人群中,SePP可能表明血管脆弱性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血管生物学 血管生物学
- 生物化学 生物化学
背景情况:
- 周围动脉疾病 (PAD) 是腹膜透析 (PD) 患者的常见并发症.
- 在PD患者中,腕指数 (ABI) 的解释可能具有挑战性,需要使用替代生物标志物.
- 蛋白P (SePP) 是一种运输蛋白,在血管健康方面具有潜在的作用.
研究的目的:
- 在接受PD的患者中调查血清SePP水平和ABI定义的PAD之间的关联.
- 探索SePP作为PD患者血管应激的潜在生物标志物.
主要方法:
- 对98名PD患者的截面分析.
- 使用自动化振荡计装置进行ABI测量 (ABI<0.9定义为PAD).
- 血清SePP水平通过酶相关免疫吸收试验 (ELISA) 测量.
主要成果:
- 20.4%的PD患者患有ABI定义的PAD.
- 患有PAD的患者年龄较大,糖尿病患病率较高,PD年龄较长,葡萄糖和C反应蛋白水平较高.
- 在患有PAD的患者中观察到较低的血清SePP度 (p < 0.001).
- 在多变量调整 (OR 0.930,p=0.032) 后,低SePP仍然与PAD独立相关.
- 在左侧和右侧,SePP与ABI正相关.
结论:
- 在PD患者中,低血清SePP水平与ABI定义的PAD独立相关.
- SePP显示了与ABI值的积极关联.
- 在PD患者中,SePP可能作为血管脆弱性的关联生物标志物,而不是诊断标志物.
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