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动态甲状腺蛋白比率作为生物标志物,用于识别乳头甲状腺癌患者,这些患者可以从低饮食中受益

Su Woong Yoo¹, Yong Min Na², Young Jae Ryu²

¹Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun-gun 58128, Jeonnam, Republic of Korea.

Diagnostics (Basel, Switzerland)

|February 13, 2026

概括

坚持低饮食 (LID) 改善了皮肤状甲状腺癌 (PTC) 患者的放射性 (RAI) 治疗反应,这些患者有显著的甲状腺蛋白 (Tg) 释放. Tg比率 (ratioTg) 可以识别受益于LID的患者.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
核医学就是核医学.

背景情况:

乳头甲状腺癌 (PTC) 的治疗通常涉及放射性 (RAI) 治疗.
评估治疗反应对于患者的治疗结果至关重要.
坚持低饮食 (LID) 是影响RAI疗效的潜在因素.

研究的目的:

评估在接受RAI治疗的PTC患者的低饮食 (LID) 坚持和治疗反应之间的关联.
研究治疗后释放的甲状腺蛋白 (Tg) 作为急性辐射反应标记物的作用.
要确定Tg比率 (ratioTg) 是否可以预测LID的好处.

主要方法:

对895名接受RAI治疗的PTC患者进行了回顾性分析.
通过尿液与肌素 (I/Cr) 的比率 (<66.2μg/g Cr表明良好的粘附) 评估LID粘附.
用后RAI Tg / 前RAI Tg计算的Tg比率 (ratioTg) 来测量辐射诱导的Tg释放;患者按比率Tg分层 (≤1对>1).

主要成果:

具有良好的LID坚持的患者与不良坚持的患者相比,显示出显著更高的比率Tg (15.7对8.9,p=0.007).
在Tg比率> 1的患者中,LID坚持与改善的治疗反应独立相关 (OR=2.004,p=0.003).
在RatioTg ≤ 1 (p=0.546) 的患者中,没有发现LID坚持和治疗反应之间的显著关联.

结论:

在接受RAI治疗的PTC患者中,LID的临床益处取决于辐射诱导的thyroglobulin释放的程度.
比 (ratioTg) 是一种有价值的标志物,用于识别可能从低饮食中受益的患者.
优化LID坚持可以提高RAI治疗结果在选定的PTC患者.

关键词:

低的饮食低的饮食皮囊甲状腺癌是什么?皮囊甲状腺癌是什么放射性是一种放射性.甲状腺球蛋白甲状腺球蛋白

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