光学连贯性断层扫描和光学连贯性断层扫描-血管扫描 末期脏疾病的慢性变化:系统性审查
Ioana-Madalina Bilha1, Stefana Catalina Bilha2, Nada Akad3
1Department of Morpho-Functional Sciences I-Histology and Pathology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Diagnostics (Basel, Switzerland)
|February 13, 2026
概括
光学连贯断层扫描 (OCT) 和OCT血管扫描 (OCTA) 揭示了末期病 (ESRD) 患者的慢性微血管变化. 这些视网膜发现可能有助于慢性病 (CKD) 的全身血管评估和监测.
科学领域:
- 眼科医生 眼科 眼科
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血管生物学 血管生物学
背景情况:
- 末期病 (ESRD) 涉及显著的微血管功能障碍.
- 视网膜和脏的微循环具有相似之处,使眼镜成像对评估系统性血管损伤有希望.
研究的目的:
- 在ESRD中使用OCT和OCTA系统地审查慢性视网膜和冠状腺变化.
- 巩固关于OCT/OCTA在ESRD患者中检测到的微血管变化的证据.
主要方法:
- 在PubMed/MEDLINE (开始至2025年6月) 的系统文献搜索中,对在ESRD患者中进行的OCT/OCTA研究进行了系统的文献搜索.
- 包括报告慢性OCT/OCTA发现的成年人临床研究;排除非英语,急性和非临床报告.
- 十七项研究符合综合研究的资格标准.
主要成果:
- 观察到一致的慢性结构和 perfusion 异常:视网膜神经纤维/质细胞层变薄,血管密度降低,状血管区域扩大,胸膜厚度降低.
- 这些视网膜变化与ESRD严重程度和全身微血管负担相关.
结论:
- 通过OCT/OCTA进行视网膜成像显示ESRD中可重现的慢性微血管变化.
- 视网膜血管查可以作为ESRD/CKD患者系统性血管评估的可访问的辅助.
- 为了将视网膜生物标志物整合到CKD监测中,需要标准化的成像协议.
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