在氧氨酸视网膜病变中的光学一致性断层扫描和血管扫描:叙述性综述
Alexandra Lori Donica1,2, Vlad Constantin Donica1, Mara Russu1,2
1Grigore T. Popa University of Medicine and Pharmacy, University Street, No. 16, 700115 Iasi, Romania.
Diagnostics (Basel, Switzerland)
|February 13, 2026
概括
氧化 (HCQ) 视网膜病变的风险与剂量和持续时间有关. 光学相干断层扫描 (OCT) 和OCT血管学 (OCT-A) 检测早期的视网膜变化,有助于及时干预以防止视力丧失.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 氧化 (HCQ) 对于自身免疫性疾病至关重要,但有视网膜毒性的风险.
- 早期发现HCQ视网膜病变对于预防不可逆转的视力损伤至关重要.
研究的目的:
- 审查关于光学一致性断层扫描 (OCT) 和OCT-血管扫描 (OCT-A) 早期检测氧化视网膜病变的文献.
- 为了确定HCQ毒性的结构和微血管生物标志物.
主要方法:
- 2017年1月至2025年2月出版的研究的叙事文献综述从PubMed.
- 包括的研究评估了使用OCT和/或OCT-A在人类受试者的HCQ毒性.
- 提取了有关患者特征,HCQ剂量和成像发现的数据.
主要成果:
- 在223项审查的研究中,88项显示了与早期HCQ毒性相关的OCT结构变化 (圆形区域,外核层,RPE).
- CT-A显示了微血管变化,如血管密度降低和状血管区域扩大.
- 这些成像检测结果往往是在功能视力障碍之前发现的.
结论:
- HCQ视网膜病变是一种严重的风险,与累积剂量,持续时间和患者因素有关.
- 超越国外地区和超越国外地区-A为亚临床视网膜毒性检测提供互补的生物标志物.
- 整合定量OCT指标可以提高查,诊断和个性化患者护理.
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