癌症患者中GFR评估:洞察力和临床影响
Alok Arora1, Parnika Shukla1, Vinay Srinivasan2
1Division of Nephrology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Cancers
|February 13, 2026
概括
对癌症患者来说,准确的球过率 (GFR) 评估至关重要. 新的指导方针建议使用CKD-EPI2021等组合方程,以更好地估计GFR,提高癌症护理和治疗准确度.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
- 临床化学 临床化学
背景情况:
- 精确的球过率 (GFR) 评估对于管理癌症患者至关重要,影响诊断,治疗和临床试验参与.
- 传统的GFR方程 (Cockcroft-Gault,MDRD) 在癌症患者中是不可靠的,原因是肉症,肌素分泌阻塞和液体转移.
- 不准确的GFR估计可能导致治疗不足,毒药物过量服用,以及被排除在关键临床试验之外.
研究的目的:
- 审查癌症患者GFR评估中的挑战.
- 在这个人群中概述不准确的GFR估计的临床影响.
- 为优化瘤学中GFR评估提出最近的建议.
主要方法:
- 对癌症患者GFR评估的当前文献和指导方针的审查.
- 对影响瘤学GFR估计的生理因素的分析.
- 综合KDIGO和美国瘤瘤学会的建议.
主要成果:
- 传统的GFR方程在癌症患者中不足.
- 使用囊素C和肌素的组合方程 (例如,CKD-EPI 2021) 提供了更好的准确性.
- 对于需要精确值的高风险患者,建议直接测量GFR.
结论:
- 优化癌症患者的GFR评估对于有效的治疗和改善结果至关重要.
- 通过更新的指南和方程可以提高患者的护理和参与研究.
- 在复杂的癌症相关场景中,可能需要进一步的研究来完善GFR估计.
相关概念视频
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
458
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
458
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
900
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
900
01:20Nursing Process for Patient and Caregiver Teaching III: Evaluation and Documentation
2.6K
Evaluation of the teaching process enables the nurse to determine if the patient's learning needs were met and if training was effective. If the expected outcomes are not met, the care plan is revised, and additional education or reinforcement is provided. Nurses can ask questions after the session or obtain feedback to assess the patient's understanding of the topic.
Nurses can use several methods to evaluate patient outcomes. For example, oral questions can assess cognitive learning,...
Nurses can use several methods to evaluate patient outcomes. For example, oral questions can assess cognitive learning,...
2.6K
01:27Nursing Clinical Information System
1.3K
Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
1.3K
01:16Clinical Trials
10.9K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
10.9K
01:11Clinical Trials: Overview
5.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K