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在循环瘤细胞上使用表面生物标志物实时监测治疗反应.
Saloni Andhari1,2,3, Jaspreet Farmaha1, Ashutosh Vashisht1
1Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Cancers
|February 13, 2026
概括
循环瘤细胞 (CTC) 为癌症监测提供了实时液体活检替代方案. 鉴定PD-L1和HER2等CTC表面生物标志物有助于治疗决策,并在组织活检难以进行时追踪最小残留疾病.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物标志物 生物标志物
背景情况:
- 循环瘤细胞 (CTC) 从瘤中流入血液中.
- 在癌症进展监测中,CTC 作为动态分子生物标志物.
- 用于生物标志物 (例如PD-L1,HER2) 分析的组织活检往往无法获得或不足,特别是在手术后或复发后.
研究的目的:
- 审查CTC表面蛋白生物标记物的临床应用的翻译潜力.
- 突出CTC作为纵向瘤评估的实时替代方案.
- 为指导免疫疗法和监测最小残留疾病 (MRD) 强调CTC分析.
主要方法:
- 审查CTC检测方法 (物理性质,像EpCAM这样的表面标记物) 的最新进展.
- 整合下一代测序 (NGS) 用于单独的CTCs的分子特征.
- 专注于在CTC上分析表面蛋白生物标记物 (PD-L1,HER2,EGFR).
主要成果:
- 新兴证据表明,CTC计数和生物标志物表达预测预后和治疗耐药性.
- CTCs能够重复,纵向评估瘤表型和治疗反应.
- 对CTC生物标志物进行分析为患者分层提供了一种临床可行的方法.
结论:
- CTCs为癌症生物标志物分析提供了一种有价值的,非侵入性的替代组织活检.
- 纵向CTC分析可以指导免疫治疗决策并有效监测MRD.
- 对于个性化癌症护理来说,CTC表面生物标记物 (PD-L1,HER2,EGFR) 的转化潜力非常重要.
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