在日本,高剂量静脉注射铁性碳素盐酸盐/无ESA的Derisomaltose治疗与癌症相关的贫血:一项回顾性单中心队列研究
Shinya Kajiura1,2,3, Yudai Ishikawa4, Yoko Mizuno1,2
1Department of Medical Oncology and Palliative Medicine, Toyama University Hospital, Toyama 930-0194, Japan.
Cancers
|February 13, 2026
概括
高剂量的静脉注射铁有效地增加了血红蛋白,并避免了在缺乏红色素形成刺激剂 (ESAs) 的日本癌症患者的输血. 这种无ESA的方法显示出良好的耐受性和对癌症相关贫血 (CRA) 的适度短期益处.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 与癌症相关的贫血 (CRA) 在日本很普遍,在日本,红色素形成刺激剂 (ESA) 无法用于化疗诱导的贫血.
- 现代静脉注射 (IV) 铁配方允许高剂量的铁补充,但在没有ESA的瘤学环境中,现实世界的数据有限.
研究的目的:
- 评估高剂量静脉铁单疗法 (铁糖盐酸或铁盐酸) 在日本CRA患者的疗效和安全性.
- 在无ESA环境中评估血红蛋白变化,输血避免和铁剂量充足度.
主要方法:
- 55名患有CRA的患者接受高剂量静脉注射铁 (铁性碳素盐酸或铁性脱脂盐酸) 的回顾性研究.
- 根据铁缺乏症表型 (绝对ID,功能ID,非ID) 将患者分类.
- 主要终点:非输血患者在~1个月内血红蛋白 (Hb) 变化;次要终点包括应答率,输血避免和安全性.
主要成果:
- 在没有输血的患者中,平均Hb在21-45天内增加了+0.92g/dL (p<0.001).
- 响应率为48.9%,而输血避免率为81.8%.
- 安全性概况很好,没有观察到输液反应或症状性低度血症.
结论:
- 高剂量的静脉铁单一疗法耐受性良好,在日本癌症患者中提供适度的短期Hb增加和高输血避免率.
- 这种无ESA的方法是对精选的CRA患者的务实选择.
- 需要进一步的前性研究来确认长期疗效和通用性.
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