针对多目标放射治疗计划的符合性指数的概括
Yong Sang1, Jun Dang1, Jianan Wu1
1Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China.
Cancers
|February 13, 2026
概括
一个新的VTV公式改进了辐射治疗中的多目标计划的符合性指数 (CI) 计算. 这一重新定义的VTV参数提供了更准确的CI,有利于乳腺癌和鼻癌治疗的临床应用.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 放射治疗规划 放射治疗规划
背景情况:
- 当前的符合性指数 (CI) 公式在多目标放射治疗计划中表现出扭曲.
- 现有CI公式中的VTV参数需要改进,以准确评估多目标计划.
研究的目的:
- 为了在多目标计划中更准确地计算CI,重新定义VTV参数.
- 为评估治疗合规性提供临床上适用的参考.
主要方法:
- 开发了一种新的VTV计算公式,解决了van't Riet和Paddick CI的局限性.
- 分析了15个乳腺癌 (BC) 和15个鼻癌 (NPC) 计划.
- 在新的和传统的CI计算之间进行了统计比较 (Wilcoxon签名等级测试,Pearson的相关性).
主要成果:
- 新的VTV计算给出了比BC和大多数NPC目标的传统方法要低得多的值 (p < 0.05).
- 因此,BC和大多数NPC目标的新CI值显著更高,表明符合性有所改善.
- 在NPC中观察到与PTV1相同的结果,这表明了针对特定目标的配方性能.
结论:
- 拟议的VTV公式通过排除邻近目标的剂量泄漏,准确地反映了目标体积的符合性.
- 与传统方法相比,这种精确的CI计算提供了更精确的处理合规性测量方法.
- 建议使用新的公式计算多目标计划中的CI,包括BC和NPC治疗.
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