相关实验视频
Updated: Feb 14, 2026

03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
860
在患有晚期皮肤状细胞癌的患者中,Cemiplimab的现实世界经验
Matteo Ravara1, Tommaso Sani1, Vincenzo D'Alonzo1
1Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
Cancers
|February 13, 2026
概括
塞米普利马布在治疗晚期皮肤状细胞癌 (cSCC) 中表现出高的疗效和耐受性. 这项现实研究表明,在患有cSCC的老年和脆弱患者中,持续性反应和良好的安全性.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 免疫治疗是一种免疫疗法.
背景情况:
- 皮肤状细胞癌 (cSCC) 是一种常见的,可能危及生命的皮肤恶性瘤.
- 抗PD-1抗体Cemiplimab在临床试验中对晚期cSCC显示出显著的疗效.
- 塞米普利马布是已知的高级cSCC的第一线治疗方法.
研究的目的:
- 评估Cemiplimab在局部晚期或转移性cSCC患者中的实际有效性和安全性.
- 在现实环境中评估临床结果,包括客观反应率 (ORR) 和与治疗相关的不良事件 (TRAE).
主要方法:
- 对27名局部晚期或转移性cSCC的成年患者进行了回顾性观察性研究,这些患者接受了CEMIPLIMAB治疗.
- 患者每三周接受350毫克的塞米普利马布.
- 从2019年12月到2024年6月收集的临床结果和TRAE数据.
主要成果:
- 客观反应率 (ORR) 为66.6% (22.2%的完整反应),疾病控制率 (DCR) 为77.7%.
- 没有达到无进展生存 (mPFS) 和总生存 (mOS) 的中位数;两年PFS和OS率分别为65.2%和71%.
- 治疗耐受性良好,11.1%的患者经历了等级≥3的TRAE;三名患者因TRAE而停止治疗.
结论:
- 现实数据证实,在老年和脆弱的cSCC患者中,塞米普利马布的持久客观反应率很高.
- 在这个患者群体中,Cemiplimab表现出良好的耐受性和长时间的治疗持续时间.
- 这些发现支持在常规临床实践中将塞米普利马布作为先进cSCC的有效一线治疗方法.
相关概念视频
What is an Experiment?
19.1K
An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
19.1K
Overview of Advanced Functional Groups
30.4K
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
30.4K
The Stanford Prison Experiment
24.8K
The famous and controversial Stanford Prison Experiment, conducted by social psychologist Philip Zimbardo and his colleagues at Stanford University, demonstrated the power of social roles, social norms, and scripts.
24.8K
Extraction: Advanced Methods
1.2K
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.2K
Thomson's e/m Experiment
7.0K
In a beam of charged particles created by a heated cathode, the particles move at different speeds. However, many applications need a beam with uniform particle speeds. An arrangement known as a velocity selector uses electric and magnetic fields to pick particles with a particular speed from the beam.
A particle with charge q, speed v, and mass m enters an area from the top, where the magnetic and electric fields are perpendicular both to the particle's motion and to one another. The magnetic...
A particle with charge q, speed v, and mass m enters an area from the top, where the magnetic and electric fields are perpendicular both to the particle's motion and to one another. The magnetic...
7.0K
Controls in Experiments
18.5K
When conducting an experiment, it is crucial to have control to reduce bias and accurately measure the dependent variables. It also marks the results more reliable. Controls are elements in an experiment that have the same characteristics as the treatment groups but are not affected by the independent variable. By sorting these data into control and experimental conditions, the relationship between the dependent and independent variables can be drawn. A randomized experiment always includes a...
18.5K

