与结肠直肠癌风险相关的炎症性细胞因子和氧化应激标记物:在韩国人口中进行的一项案例对照研究
Eunjung Park1, Seungju Baek2, Jin-Kyoung Oh1
1Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang 10408, Republic of Korea.
Cancers
|February 13, 2026
概括
增加的炎症标志物,如介白素-6 (IL-6) 与韩国人的结直肠癌 (CRC) 风险较高有关. 肥胖可能会影响这些关联,突出炎症炎症.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 慢性炎症和氧化压力与结直肠癌 (CRC) 的发展有关.
- 在亚洲人群,特别是韩国人群中,这些因素的前性证据有限.
研究的目的:
- 在韩国人群中调查循环炎性细胞因子,氧化应激标志物和CRC风险之间的关联.
主要方法:
- 在韩国国家癌症社区 (KNCCC) 队列中进行的一项案例-队列研究.
- 血清IL-6,TNF-α,IL-1β,IFN-γ,IL-10,ROS和NO的水平在128例CRC病例和822名子队列参与者中被测量.
- 危险比率 (HRs) 估计使用Cox比例危险模型与巴洛的权重.
主要成果:
- 较高的血清IL-6水平与CRC风险增加有很强的关联 (HRs高达10.22).
- 可检测到的IL-1β和IFN-γ水平也与较高的CRC风险显著相关 (HRs:2.16和1.53).
- 肥胖改变了TNF-α,IL-10和NO的关联,但不是IL-6,IL-1β或ROS.
结论:
- 较高的IL-6,IL-1β,IFN-γ和氧化 (NO) 与CRC风险增加有关,这表明它们可能是早期生物标志物.
- 肥胖可能会影响某些炎症和氧化应激标志物与CRC风险之间的关系.
- 这些发现强调了系统性炎症和氧化应激在结直肠癌发生中的作用.
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