在神经母细胞瘤中检测和描述循环瘤细胞群
Zoe Bell1, Swathi Merugu1, David Jamieson2
1Wolfson Childhood Cancer Research Centre, Translational & Clinical Research Institute, Newcastle University Centre for Cancer, Herschel Building, Newcastle upon Tyne NE1 7RU, UK.
Cancers
|February 13, 2026
概括
在神经母细胞瘤患者中使用成像流细胞计检测检测到循环瘤细胞 (CTC) 集群. 这些集群主要是异型的,即使单个CTC缺席,也可能在转移中发挥作用.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 神经母细胞瘤 (NB) 是一种常见的儿科癌症,高风险病例的预后不佳.
- 循环瘤细胞 (CTC) 是癌症扩散和转移的关键.
- CTCs可以作为单细胞或集群 (同型或异型) 存在.
研究的目的:
- 调查神经母细胞瘤患者血液样本中CTC集群的存在和特征.
- 使用现有的ImageStreamX成像流细胞计数据进行集群分析.
主要方法:
- 分析24名神经母细胞瘤患者的ImageStreamX成像流动细胞计数据.
- 免疫光和亮场成像用于集群识别.
- IDEAS图像分析软件用于定量评估.
主要成果:
- 平均每个样本检测到87个CTC集群 (范围:0-725).
- 绝大多数集群 (93.9%) 是异型的,只有6.1%是同型的.
- 在3名患者中,尽管没有可检测的单个CTC,但仍发现了集群.
结论:
- 图像流细胞计对于检测和表征神经母细胞瘤中CTC集群是有效的.
- 在NB患者的血液中,CTC集群,特别是异型集群,很普遍.
- 需要进一步的研究来了解CTC集群在神经母细胞瘤转移中的作用.
相关概念视频
Coronary Circulation
7.6K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
7.6K
Fetal Circulation
3.3K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
3.3K
Cluster Sampling Method
14.9K
Appropriate sampling methods ensure that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
To choose a cluster sample, divide the population into clusters (groups) and then randomly select some of the clusters. All the members from these clusters are in the cluster sample. For example, if you randomly sample four departments from your...
To choose a cluster sample, divide the population into clusters (groups) and then randomly select some of the clusters. All the members from these clusters are in the cluster sample. For example, if you randomly sample four departments from your...
14.9K
Vesicular Tubular Clusters
3.3K
After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
With the help of motor proteins such...
3.3K
Overview of Pulmonary Circulation
3.7K
The pulmonary circulation is a vital system in our body that acts as a bridge between the respiratory and cardiovascular systems. It serves as a transport network for deoxygenated blood from the heart to the lungs and then returns oxygen-rich blood back to the heart.
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
3.7K
Overview of Systemic and Pulmonary Circulation
11.3K
The systemic and pulmonary circuits are crucial components of the circulatory system, working together to transport blood between the heart, lungs, and the rest of the body. The process begins with pulmonary circulation, where deoxygenated blood is pumped from the right ventricle to the lungs via the pulmonary trunk and arteries. Upon reaching the lungs, the blood becomes oxygenated and returns to the heart, specifically to the left atrium, via the pulmonary veins.
The oxygenated blood is sent...
The oxygenated blood is sent...
11.3K


