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灰色物质体积和认知功能在儿科后腔瘤幸存者的认知功能
Kristien Bullens1, Charlotte Sleurs1,2, Jeroen Blommaert1,3
1Department of Oncology, KU Leuven, 3000 Leuven, Belgium.
Cancers
|February 13, 2026
概括
后腔瘤 (PFT) 幸存者显示灰质体积 (GMV) 变化和认知缺陷,特别是在辐射后. 像丘脑这样的大脑区域的GMV减少与这些患者的工作记忆较差有关.
科学领域:
- 神经成像是一种神经成像.
- 神经心理学 神经心理学
- 辐射瘤学 辐射瘤学
背景情况:
- 后腔瘤 (PFTs) 需要放射治疗,可能导致大脑损伤.
- 放射治疗可以影响皮质和皮质下大脑结构.
研究的目的:
- 为了调查PFT幸存者的灰质体积 (GMV) 变化.
- 探索GMV变化与PFT幸存者的认知功能之间的关系.
- 为了比较受辐射和未受辐射的PFT幸存者之间的GMV和认知功能.
主要方法:
- 使用T1加权的MRI扫描来量化GMV,使用基于voxel和基于区域的体积计.
- 用维克斯勒成人智力尺度-IV (WAIS-IV) 和特定领域的测试来评估认知表现.
- 该研究包括18名PFT幸存者和21名匹配的对照.
主要成果:
- 经过PFT的幸存者在特定的大脑区域呈现了降低的GMV,包括左尾状和左.
- 基于区域的分析显示,在幸存者中,皮下区域的GMV较低,而左下部区域的GMV较高.
- 脊辐射与双边头脑层和右腹脑区的GMV减少有关,双边中部区域的GMV更高.
- 与对照组相比,幸存者在大多数认知领域的表现较差,除了复杂的注意力和认知灵活性.
- 在幸存者中,双边丘脑和右腹脑区的GMV与工作记忆性能有积极的相关性.
结论:
- 经过PFT的幸存者在GMV和认知能力上表现出显著的改变.
- 脊辐射加剧了PFT幸存者的GMV偏差.
- 减少的GMV与PFT幸存者的认知能力下降有关,突出显示了治疗的长期影响.
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