解码生殖泌尿瘤学中的微生物群:生物机制和临床影响-叙述性综述
Irene Caramella1, Chiara Abeni1, Sara Cherri1
1Department of Clinical Oncology, Fondazione Poliambulanza, 25124 Brescia, Italy.
Cancers
|February 13, 2026
概括
人类微生物群通过影响瘤生物学和治疗反应来影响泌尿生殖系统癌症. 调节这些微生物生态系统可能会改善癌症治疗和治疗结果.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 生殖尿路 (GU) 恶性瘤表现出显著的异质性.
- 治疗耐药性是GU癌症治疗的一个主要挑战.
- 影响瘤进展和治疗反应的与宿主相关的因素需要进一步调查.
研究的目的:
- 审查微生物群在生殖尿路癌症中的作用.
- 探索将微生物群与癌症联系起来的生物机制.
- 为了将微生物特征与疾病特征和治疗结果相关联.
主要方法:
- 本综述综合了临床前,转化和临床证据.
- 专注于脏,前列腺,膀和丸癌症.
- 检查生物机制和临床相关性.
主要成果:
- 改变的微生物特征与瘤致癌信号传递和瘤微环境有关.
- 微生物群的组成会影响对全身疗法的反应,尤其是免疫疗法.
- 观察数据表明微生物群影响瘤与宿主相互作用.
结论:
- 与宿主相关的微生物群在生殖尿路癌症生物学中发挥着重要作用.
- 微生物群调制显示出影响治疗活动的潜力.
- 这些发现支持微生物群作为GU癌症精准医学的目标.
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