在高风险结直肠肝转移中,短期新辅助药CAPOX Plus Bevacizumab后的瘤和手术结果
Yawen Dong1, Madita Tschoegl1, Florian Lehner1
1Department of Surgery, HPB Center, Clinic Favoriten, Health Network Vienna and Sigmund Freud Private University, 1100 Vienna, Austria.
Cancers
|February 13, 2026
概括
使用CAPOX和bevacizumab的短期新辅助疗法对高风险结直肠肝转移 (CRLM) 有效. 这种疗法实现了显著的反应与可管理的毒性,支持其在选定的患者的使用.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 对高风险结直肠肝转移 (CRLM) 的新辅助疗法的最佳持续时间进行了辩论.
- 长时间的化疗可以增加毒性并延迟手术.
- 短期的新辅助药策略旨在平衡瘤选择和反应,并尽量减少发病率.
研究的目的:
- 评估CRLM高风险的两周期新辅助药CAPOX加贝瓦齐祖马布疗法的疗效和安全性.
- 评估治疗耐受性,反应率和生存结果.
- 为了确定一个缩短的新辅助方法的可行性.
主要方法:
- 在2014-2024年期间治疗的57名CRLM患者的回顾性分析.
- 在切除肝脏之前,患者接受了两轮新辅助药CAPOX加贝瓦齐祖马布.
- 收集了临床病理学数据,治疗耐受性和反应评估 (生物化学,放射学,病理学).
主要成果:
- 53.7%的患者实现了>50%的瘤标志物减少;31.6%的患者表现出部分放射性反应.
- 病理学评估显示瘤回归良好 (TRG 3在57.1%中).
- 3级以上的不良事件发生在10.6%的患者中;辅助治疗和较小的瘤 (<5厘米) 与改善的生存率相关.
结论:
- 两个周期的CAPOX加贝瓦西祖马布治疗方案对高风险的CRLM有效和安全.
- 这种短期的方法产生了有意义的反应,具有可接受的毒性.
- 该策略支持提供新辅助疗法,同时限制在精选的CRLM患者中的累积毒性.
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