通过电解质凝-喷雾干燥制备的奇托桑/碳甲基纤维素纳米复合物,用于控制安皮西林输送和增强抗菌活性
Anh Dzung Nguyen1, Vinh Nghi Nguyen2, Vu Hoa Tran1
1Institute of Biotechnology and Environment, Tay Nguyen University, Buon Ma Thuot 630000, Vietnam.
Polymers
|February 13, 2026
概括
奇托/碳甲基纤维素纳米复合物被开发为安培的有效载体. 这些环保材料对黄金葡萄球菌具有显著的抗菌活性,为抗生素输送提供了有前途的方法.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 纳米技术纳米技术
背景情况:
- 酸盐和碳素甲基纤维素是生物相容的聚合物,具有药物输送潜力.
- 开发有效的抗生素载体,如安培,对于对抗细菌感染至关重要.
研究的目的:
- 使用电解质凝喷雾干燥制造奇托桑/碳甲基纤维素 (C/M) 纳米复合材料.
- 为了评估它们作为运输皮素输送的载体的有效性.
- 评估开发的纳米复合材料的抗菌性能.
主要方法:
- 通过电解质凝喷雾干燥制造C/M纳米复合材料.
- 使用FTIR进行粒子大小,泽塔潜力和表面相互作用的表征.
- 评估安皮西林封装效率和受控释放动力学.
- 使用MIC和MBC测定对黄金葡萄球菌的抗菌活性的评估.
主要成果:
- 最佳的C/M纳米复合材料配方 (2:1比率) 实现了71.1%的回收率和82.4%的安比西林封装效率.
- 纳米复合材料显示出控制的安比西林释放.
- 观察到对黄金葡萄球菌有显著的抗菌活性,与自由安皮西林相比,MIC (3.2微克/毫升) 和MBC (5.3微克/毫升) 较低.
结论:
- 奇托/碳甲基纤维素纳米复合物是安培的有效和环保的载体.
- 这些纳米复合材料在抗生素输送和抗菌应用方面表现出有前途的潜力.
- 开发的材料提供了一种可行的策略,以提高抗生素的有效性和打击细菌耐药性.
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