在通过皮肤输送药物中的聚合物膜基系统.
Laura Donato1, Paola Bernardo1
1Institute on Membrane Technology "Enrico Drioli" (National Research Council of Italy), 87036 Rende, Italy.
Polymers
|February 13, 2026
概括
控制药物输送系统 (CDDS) 提供精确的治疗方法. 透皮药物递送系统 (TDDS) 提供了一种非侵入性途径,通过先进的膜技术提高患者的服药性,减少副作用.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 膜技术 膜技术 膜技术
- 制药科学 制药科学
背景情况:
- 控制药物输送系统 (CDDS) 对于精确和定制的疾病治疗至关重要.
- 通过皮肤递送药物系统 (TDDS) 为口服提供了一个非侵入性的替代方案,绕过胃问题和第一通代谢.
- 开发有效的TDDS需要采用多学科的方法,整合聚合物化学,材料科学和制药科学.
研究的目的:
- 提供对受控药物输送系统的全面概述.
- 从膜工程的角度来看,专注于通过皮肤递送药物系统 (TDDS).
- 讨论基于聚合物膜的TDDS的材料和策略.
主要方法:
- 对控制和透皮药物输送系统的现有文献的审查.
- 分析被动和活跃的通过皮肤递送策略.
- 讨论各种基于透皮膜的释放系统,包括贴片,混合矩阵膜和印制膜.
主要成果:
- TDDS利用皮肤进行非侵入性药物管理,改善患者的服药性,避免全身副作用.
- 聚合物膜是TDDS配方的关键组成部分,需要在聚合物化学和材料科学方面的专业知识.
- 积极的和被动的策略,以及各种基于膜的系统,都被用于有效的通过皮肤递送药物.
结论:
- 通过皮肤递送药物系统 (TDDS) 代表了控制药物递送的重大进步,提供了更好的治疗结果.
- 膜工程在TDDS的设计和优化中发挥着至关重要的作用.
- 不同科学学科的整合对于TDDS技术的持续创新和应用至关重要.
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