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从聚卡普罗拉克微粒中同时释放cytarabine和富含聚醇的提取物,以治疗白血病

Jenifer Leyva Castro¹, Laura A de la Rosa², Emilio Álvarez Parrilla²

¹Laboratorio de Nanomedicina, Instituto de Ingeniería y Tecnología, Universidad Autónoma de Ciudad Juárez, Ciudad Juárez 32310, Mexico.

|February 13, 2026

概括

聚合物微粒可携带白血病药物cytarabine和果多来改善化疗. 这些系统显示持续释放和良好的生物相容性,有助于组合治疗的发展.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
药理学药理学是指药理学的学科.

背景情况:

白血病治疗面临的挑战是化疗的全身毒性.
基于聚合物的药物输送系统有可能提高疗效并减少副作用.
组合治疗方法对于改善治疗结果至关重要.

研究的目的:

开发聚乙烯 (PCL) 微粒,用于同时输送细胞氨基酸 (ARA-C) 和来自北瓜的多提取物 (PRE).
描述共载微粒的物理化学特性和体外释放动力学.
评估开发的配方的细胞相容性.

主要方法:

使用双乳液溶剂蒸发方法制造PCL微粒.
鉴定包括显微镜 (光学,SEM),DLS,泽塔电位,UV-Vis,Folin-Ciocalteu测定和FTIR光谱.
进行了体外药物释放研究和纤维细胞活力测试.

主要成果:

微粒体表现出受控的形态,尺寸和体性质,具有不同的药物和提取物载荷.
对ARA-C和PRE.的封装效率和持续释放概况均被观察到.
释放动力学表明扩散和矩阵控制的机制.
初步测定表明PCL微粒子配方的细胞兼容性良好.

结论:

PCL微粒作为可复制的系统,用于共同封装和控制细胞和富含多提取物的释放.
这些发现支持开发用于白血病治疗的先进组合药物输送策略.
该研究强调了基于PCL的系统在提高化疗性能和减轻毒性的潜力.

关键词:

癌症癌症癌症癌症癌症运营商运营商运营商运营商运营商运营商化疗化疗是一种化学疗法.细胞氨酸 (cytarabine) 是一种送货送货送货送货送货送货乳液乳液是一种乳液.提取物提取物提取物颗粒颗粒颗粒的粒子聚合物聚合物的高分子.聚醇是一种多醇.

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