用于3D打印骨植入物的生物活性聚合物复合材料:系统性审查
Anastassiya Khrustaleva1, Dmitriy Khrustalev1, Azamat Yedrissov1
1School of Pharmacy, Karaganda Medical University, Gogol Street 40, Karaganda 100008, Kazakhstan.
Polymers
|February 13, 2026
概括
用于骨架的生物活性聚合物复合物显示出希望,但缺乏多功能性和体内验证. 未来的研究应该专注于将抗菌剂和生物活性分子纳入增强再生医学应用中.
科学领域:
- 再生医学是一种再生医学.
- 生物材料科学 生物材料科学
- 材料工程 材料工程 材料工程
背景情况:
- 基于聚合物的生物活性复合物对再生医学至关重要.
- 合成热塑性聚合物如聚乳酸 (PLA) 和聚烯酸 (PCL) 广泛用于承载性骨架.
- 目前的研究经常使用酸 (HA) 或生物活性玻璃 (BG) 进行骨质导电.
研究的目的:
- 确定用于骨组织工程的生物活性聚合物复合材料的趋势和知识差距.
- 检查负载支架的材料设计的翻译相关性.
- 专注于合成热塑性聚合物和增材制造.
主要方法:
- 546个出版物的图书统计和内容分析 (2016-2025年).
- 对106项相关研究进行选和选择.
- 对生物活性复合材料的研究轨迹的分析.
主要成果:
- 大多数研究使用PLA或PCL复合材料与HA或BG,实现骨质导电性但有限的多功能性.
- 抗菌剂,离子释放成分和天然生物活性分子的代表性不足.
- 不到20%的研究包括体内验证,这表明需要更多的临床前研究.
结论:
- 为了增强具有多功能性的生物活性聚合物复合材料,存在显著的空间.
- 未来的研究应该优先考虑纳入各种生物活性剂,并增加体内验证.
- 需要一个结构化的框架来设计下一代骨组织工程材料.
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