脂肪质量与衰老有关,而不是更年期过渡
Carmen Gabriela Barbu1,2, Irina Manuela Nistor1, Alice Albu1,2
1Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Healthcare (Basel, Switzerland)
|February 13, 2026
概括
中年女性中年女性.
科学领域:
- 内分泌学和新陈代谢学
- 妇女健康 妇女健康
- 身体组成分析 身体成分分析
背景情况:
- 中年女性经历体重和脂肪分布的变化,但原因 (衰老,更年期,生活方式) 尚不清楚.
- 更年期显著影响女性生理学,可能会影响身体组成.
- 了解这些变化对于妇女健康和代谢性疾病预防至关重要.
研究的目的:
- 用DXA扫描来比较绝经前和绝经后妇女的身体脂肪分布.
- 研究年龄,更年期和BMI对身体脂肪参数的影响.
- 确定中年妇女体脂肪分布变化的预测因素.
主要方法:
- 使用月经骨密度扫描 (DXA) 对171名女性 (45-55岁) 的截面分析.
- 在更年期前 (n=50) 和更年期后 (n=121) 妇女之间比较体质成分参数 (总体,安卓,肌肉脂肪%).
- 多变量线性回归以检查体脂结果与BMI,年龄和更年期状态等预测因素之间的关联.
主要成果:
- 在更年期前和更年期后的两组之间,无显著差异的安卓/gynoid脂肪百分比或比率.
- 体重指数 (BMI) 是身体脂肪分布的唯一显著预测指标.
- 总体脂肪百分比与年龄正相关;更年期开始年龄与BMI相关. 早期的绝经后显示,随着更年期以来的岁月,Android/gynoid比率增加.
结论:
- 年龄与增加的总体脂肪相关,但BMI或更年期状态无关.
- 在更年期后的早期,Android/gynoid脂肪比率随着更年期开始的时间而增加.
- 该研究观察到更年期开始的中位数年龄为48岁,比其他高加索研究报告的年龄更早.
相关概念视频
01:28Menopause
5.0K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
5.0K
02:31Phase Transitions
23.3K
Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
23.3K
02:58Properties of Transition Metals
30.1K
Transition metals are defined as those elements that have partially filled d orbitals. As shown in Figure 1, the d-block elements in groups 3–12 are transition elements. The f-block elements, also called inner transition metals (the lanthanides and actinides), also meet this criterion because the d orbital is partially occupied before the f orbitals.
30.1K
01:58Cooperative Allosteric Transitions
8.9K
Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
8.9K
02:39Phase Transitions: Vaporization and Condensation
21.6K
The physical form of a substance changes on changing its temperature. For example, raising the temperature of a liquid causes the liquid to vaporize (convert into vapor). The process is called vaporization—a surface phenomenon. Vaporization occurs when the thermal motion of the molecules overcome the intermolecular forces, and the molecules (at the surface) escape into the gaseous state. When a liquid vaporizes in a closed container, gas molecules cannot escape. As these gas phase molecules...
21.6K
02:33Phase Transitions: Sublimation and Deposition
20.3K
Some solids can transition directly into the gaseous state, bypassing the liquid state, via a process known as sublimation. At room temperature and standard pressure, a piece of dry ice (solid CO2) sublimes, appearing to gradually disappear without ever forming any liquid. Snow and ice sublimate at temperatures below the melting point of water, a slow process that may be accelerated by winds and the reduced atmospheric pressures at high altitudes. When solid iodine is warmed, the solid sublimes...
20.3K