脑卒中幸存者运动能力的可修改和不可修改预测因素:系统性审查
Klaske van Kammen1, Lotte A J Verkuijlen1,2, Ana B Nasser1,2
1Department of Rehabilitation Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Healthcare (Basel, Switzerland)
|February 13, 2026
概括
像BMI和力量这样的可修改因素,以及像年龄和糖尿病这样的不可修改因素,显著预测了中风幸存者的运动能力. 了解这些预测因素有助于个性化康复.
科学领域:
- 康复医学 康复医学 康复医学
- 心血管生理学心血管生理学
- 神经学 神经学
背景情况:
- 卒中幸存者经常经历运动能力的减少,影响长期健康和康复.
- 识别运动能力的预测因素对于优化康复策略至关重要.
- 了解可修改和不可修改的因素可以提高治疗个性化.
研究的目的:
- 系统地审查和识别中风幸存者的运动能力 (VO2峰值) 的可修改和不可修改预测因素.
- 为优化康复治疗提供信息,以改善长期健康结果.
- 引导医疗保健专业人员量身定制康复计划.
主要方法:
- 在PubMed,EMBASE,CINAHL和Web of Science数据库中的系统文献搜索.
- 包括在多变量回归模型中分析的预测因素的成年中风幸存者的VO2峰值测量的研究.
- 使用量化研究的麦克马斯特批判性审查表格进行偏差风险评估.
主要成果:
- 包括17篇文章,确定了可修改的显著预测因素:BMI,脂肪量,下肢力量,基线VO2峰值,训练强度和感知疲劳.
- 重要的不可修改的预测因素包括年龄,性别,糖尿病和中风特异性因素.
- 这些因素被证明可以显著预测VO2峰值水平或变化.
结论:
- 可修改和不可修改的预测因素都在优化中风后的运动能力方面发挥着重要作用.
- 通过考虑这些不同的预测因素,可以实现个性化治疗计划.
- 建议进行进一步的研究,以开发一种全面的预测模型,用于中风幸存者的运动能力.
相关概念视频
00:57Modified Boxplots
11.3K
A standard box and whisker plot informs us about the spread of the data in a given sample. One can identify the minimum value, maximum value, first quartile value, second quartile or median value, and third quartile.
However, the box plot does not tell the reader about outliers - values that lie far from the center of the data. We can modify the standard box and whisker plot to identify the outliers and visualize the actual spread of the data in a sample.
Initially, we calculate the adjusted...
However, the box plot does not tell the reader about outliers - values that lie far from the center of the data. We can modify the standard box and whisker plot to identify the outliers and visualize the actual spread of the data in a sample.
Initially, we calculate the adjusted...
11.3K
01:19Antiasthma Drugs: Leukotriene Modifiers
1.9K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
1.9K
01:47Lung Capacity
56.4K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.4K
01:30Modified-Release Drug Delivery Systems: Bioavailability
2
Modified-release (MR) dosage forms are designed to extend drug release over time, thereby maintaining stable plasma concentrations and reducing dosing frequency. However, their bioavailability is typically below 100% due to incomplete drug release and presystemic metabolism, and limitations in drug permeability across the gastrointestinal epithelium, all of which can restrict the fraction of the drug reaching systemic circulation. Consequently, studying the in vivo bioavailability of MR...
2
01:19Modified-Release Drug Delivery Systems: Overview
3
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
3
01:23Modified-Release Drug Delivery Systems: Classification
2
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
2