开发和验证基于光学传感器的自动化尿液流量计,用于实时监测患者
Piyush Hota1,2,3,4, Adithya Shyamala Pandian2,3,4,5, Rodrigo E Domínguez3,4,6
1School for Engineering of Matter, Transport & Energy, Ira A. Fulton School of Engineering, Tempe, AZ 85287, USA.
Sensors (Basel, Switzerland)
|February 13, 2026
概括
我们开发了一种自动化尿液流量计,P-meter,用于精确,实时监测尿液输出. 这种具有成本效益的设备有助于早期检测急性损伤 (AKI),通过在肌素水平发生变化之前跟踪尿液输出.
科学领域:
- 生物医学工程 生物医学工程
- 腎臟病學 (nephrology) 是一種醫學專業.
- 医疗器械 医疗器械
背景情况:
- 急性损伤 (AKI) 是住院患者的常见并发症,由于血清肌素升高的延迟,早期检测受到阻碍.
- 尿量减少 (UO) 是AKI的早期指标,但手动监测是不可靠的,劳动密集型.
研究的目的:
- 开发和验证一个具有成本效益的自动化设备,用于精确的实时尿液输出监测.
- 通过加强UO监测,改善AKI的早期检测.
主要方法:
- 使用非接触式光学传感器,环静电和微控制器自动化的P-meter的开发.
- 在动物研究中,对三种原型 (V1,V2,V3) 与金标准重力测量测量进行了超过285小时的验证.
- 代改进,专注于微型化,流体动力学和传感器定位.
主要成果:
- 优化的V3 P-meter原型表现出高精度 (R2 = 0.9889,平均误差为-0.1 mL,达成94.18%的协议).
- 与早期的原型相比,该设备显示出更好的精度,稳定性和流量精度.
- 该P-meter提供了比现有的商业系统更低的成本准确的UO监控.
结论:
- 皮度计为实时尿量监测提供了可靠且具有成本效益的解决方案.
- 这项技术可以促进AKI的早期检测,从而有可能改善患者的治疗结果.
- 自动化UO监测代表了重症监护和科的重大进步.
相关概念视频
01:32Filtration and Urine Formation
53.9K
The function of the kidneys is to filter, reabsorb, secrete, and excrete. Every day the kidneys filter nearly 180 liters of blood, initially removing water and solutes but ultimately returning nearly all filtrates into circulation with the help of osmoregulatory hormones. This process removes wastes and toxins but is also crucial to maintain water and electrolyte levels. Most of these functions are performed by the tiny but numerous nephrons contained within the kidneys.
53.9K
01:22Renal Drug Excretion: Effect of Urine pH, Flow Rate, and Drug pKa
608
The pH of urine, the drug's pKa, and the urine flow rate are vital parameters for drug reabsorption and excretion. Urinary pH varies between 4.6 and 8.0 and is influenced by diet, drug intake, and the patient's pathophysiology. It affects a drug's ionization state and reabsorption. For instance, carbohydrate-rich food produces alkaline urine promoting drug excretion, while proteins and certain medications like ascorbic acid lead to acidic urine enhancing reabsorption.
The pKa of a...
The pKa of a...
608
02:57Real Time RT-PCR
65.4K
Real-time reverse transcription-polymerase chain reaction, or Real-time RT-PCR, is an analytical tool used to determine the expression level of target genes. The method involves converting mRNA to complementary DNA with the help of an enzyme known as reverse transcriptase, followed by the PCR amplification of the cDNA. These two processes can be performed simultaneously in a single tube or separately as a two-step reaction.
The real-time quantification of the number of amplified products is...
The real-time quantification of the number of amplified products is...
65.4K
01:29Reliability and Validity
14.1K
Reliability and validity are two important considerations that must be made with any type of data collection. Reliability refers to the ability to consistently produce a given result. In the context of psychological research, this would mean that any instruments or tools used to collect data do so in consistent, reproducible ways.
14.1K
01:26Urine Studies II: Urine Culture and Sensitivity Test
1.3K
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
1.3K
01:10In Vitro Drug Release Testing: Overview, Development and Validation
368
In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
368