无电池的RFID驱动植入的神经传感器和刺激器的实验验证
Luís Eduardo Pedigoni Bulisani1, Marco Antonio Herculano1, Carolina Chen Pauris1
1Department of Research and Postgraduate Studies, Jundiaí Medical School, Rua Francisco Telles, 250, Vila Arens, Jundiaí 13202-550, SP, Brazil.
Sensors (Basel, Switzerland)
|February 13, 2026
概括
这项研究验证了一种无电池,RFID驱动的神经接口,用于神经信号采集和刺激. 无线系统成功地在老鼠中引起了运动反应,证明了传统植入物的可行替代方案.
科学领域:
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
- 植入式设备可以植入设备.
背景情况:
- 神经损伤会破坏神经传输,影响生活质量.
- 由于内部电池,目前的植入式刺激器寿命有限,需要重复手术.
研究的目的:
- 为了实验验证无电池,无线电频率识别 (RFID) 驱动的神经平台.
- 为了实现无线神经接口的技术准备6级 (TRL-6) 验证.
主要方法:
- 开发了一种具有可调节模拟前端 (高达93dB增益) 和双相电流控制刺激器的原型.
- 进行了基准测试,猪组织评估,并在Wistar大鼠 (n=3) 上进行了为期三个月的体内试验.
主要成果:
- 在基板测试中实现了2.2dB的增强精度和精确的刺激定时.
- 通过RFID通过20毫米的生物组织保持稳定的3.3V无线电源链接.
- 在无线体内,在安全的操作温度 (<28°C) 下,在无线体内引起总运动反应方面表现出100%的成功率.
结论:
- 无电池,RFID驱动的神经接口在功能上可用于无线信号采集和刺激.
- 这种架构支持高级神经接口的系统级验证.
- 该技术为神经治疗提供了一个有希望的,不那么侵入性的替代方案.
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