我们应该继续在西班牙为神经内分泌瘤的肝转移进行肝移植吗?
Andrea Boscà1, Eva M Montalvá1,2, Marina Vila-Tura3
1Department of Hepatobiliopancreatic Surgery and Transplantation, La Fe Health Research Institute (IIS La Fe), La Fe University Hospital, 46026 Valencia, Spain.
Journal of clinical medicine
|February 13, 2026
概括
在西班牙的转移性神经内分泌瘤 (NETs) 肝移植 (LT) 显示出适度的结果. 坚持严格的选择标准,如米兰标准,对于改善患者存活率至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 移植手术 移植手术
背景情况:
- 对于神经内分泌瘤 (NETs) 的肝移植 (LT) 在西班牙缺乏全面的多中心结果数据.
- 审计移植瘤学结果对于完善患者选择和提高长期存活率至关重要.
- 本研究解决了对转移性NET的LT国家结果数据的需求.
研究的目的:
- 审查西班牙转移性NET的LT国家结果.
- 评估米兰标准对患者存活率的影响.
- 确定影响LT对NET长期成功的因素.
主要方法:
- 追溯观察研究分析了13个西班牙中心 (1995-2024) 的数据.
- 包括91名为NET接受LT的患者.
- 患者被分为Milan IN (符合标准) 和Milan OUT (不符合标准) 两组.
主要成果:
- 整体复发率为57.1%,死亡率为51.6%.
- 米兰IN (71.0%) 与米兰OUT (58.0%) 的五年整体存活率显著更高.
- 五年无病生存率 (DFS) 为米兰IN的58.8%,米兰OUT的36.3% (不具有统计学意义).
结论:
- 严格遵守米兰标准对于优化NET的LT长期生存至关重要.
- 结合现代预后因素与严格的选择是必不可少的.
- 通过严格的患者选择和潜在的桥梁或降级疗法的使用,预计未来的治疗结果将会有所改善.
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