脑血管学诱导的内皮和组织病理变化的基础细胞机制
Zülfikar Özgür Ertuğrul1, Mehmet Cudi Tuncer2, Mehmet Uğur Karabat3
1Department of Radiology, Gazi Yaşargil Training and Research Hospital, University of Health Sciences, Diyarbakır 21090, Turkey.
Journal of clinical medicine
|February 13, 2026
概括
脑血管造影可以通过氧化应激和炎症损害血管. 了解这些影响是改善手术安全和大脑血管疾病治疗患者结果的关键.
科学领域:
- 神经科学是一个神经科学.
- 血管生物学 血管生物学
- 病理学 病理学 病理学
背景情况:
- 脑血管造影对于诊断和治疗脑血管疾病至关重要.
- 它对血管完整性和细胞平衡的影响需要彻底调查.
研究的目的:
- 系统地审查从脑血管造影的内皮和组织病理变化.
- 专注于氧化应激,炎症,内皮功能障碍和血脑屏障的破坏.
主要方法:
- 按照PRISMA 2020指南进行系统审查.
- 在PubMed,Scopus,科学网 (1981-2025) 中进行了搜索.
- 包括200项研究用于定性合成.
主要成果:
- 大脑血管造影会通过机械和对比作用引起内皮/微血管损伤.
- 对比剂增加反应性氧物种,损害氧化,并激活炎症 (NF-κB).
- 组织病理学显示内皮损伤,亡,微血栓和血脑屏障损伤,由并发症加剧.
结论:
- 大脑血管造影诱导内皮功能障碍和血管损伤,主要通过氧化和炎症途径.
- 优化对比剂,技术和使用保护策略可以减轻伤害.
- 需要进一步研究生物标志物和针对血管造影诱导的内皮损伤的干预措施.
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