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Updated: Feb 14, 2026

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建立和验证基于现实世界大数据和多策略分区算法的血清费里丁参考区间
Yixin Xu1,2,3, Xiaojuan Wu1,2, Junlong Zhang1,2,3
1Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Journal of clinical medicine
|February 13, 2026
概括
这项研究在当地人群中建立了新的,准确的血清费里 (SF) 参考间隔,提高了诊断精度. 以性别和年龄为特征的衍生间隔显著超过了制造商提供的范围.
科学领域:
- 临床化学 临床化学
- 生物标志物的参考间隔
- 人口健康研究 人口健康研究
背景情况:
- 建立精确的基于人群的参考间隔 (RIs) 对于解释实验室测试结果至关重要.
- 现有的血清费里丁 (SF) RIs可能不准确地反映多种人群或针对特定分析平台进行优化.
- 使用真实实世界实验室数据的间接数据驱动方法为RI确定和优化提供了一种方法.
研究的目的:
- 建立和验证基于人群的血清费里丁 (SF) 的基准区间 (RIs),使用间接的,日期驱动的方法.
- 根据性别和年龄优化SFRI的分区策略.
- 为了比较研究衍生的RI与制造商提供的RI的性能.
主要方法:
- 对29723个看似健康的个体的SF结果进行了回顾性分析.
- 使用的罗氏科巴斯e801平台用于SF测量.
- 采用Box-Cox转换,代的Tukey异常值去除,以及数据驱动的年龄截止点的决策树回归.
- 使用非参数百分位数方法估计的RI,并在独立的队列中得到验证.
主要成果:
- 男性的SF度明显高于女性 (p < 0.001).
- 在女性中,SF与年龄正相关 (r = 0.466,p < 0.001),50岁被确定为最佳年龄截止点.
- 从研究中获得的RI (男性:98.02-997.78μg/L;女性≤50:10.30-299.55μg/L;女性>50:36.61-507.00μg/L) 的验证合格率明显高于制造商RI (p<0.001).
结论:
- 在罗氏科巴斯e801平台上为当地人口建立了强大的,性别和年龄特定的SFRI.
- 间接的,多步骤的分区策略被证明是有效的RI确定.
- 该框架提供了一种可重复和通用的方法,用于确定其他生物标志物的RI.
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