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在患有抗NMDAR脑炎的儿科患者中,可溶性TREM2升高
Anna Zhou1, Changhong Ren1, Ji Zhou1
1Department of Neurology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
Journal of clinical medicine
|February 13, 2026
概括
在脑脊液 (CSF) 中,可溶性触发受体表达在骨髓细胞2 (sTREM2) 上是一种有前途的生物标志物,用于诊断和预测儿科抗N-甲基-D-酸盐受体 (NMDAR) 脑炎的结果. 较高的CSF sTREM2水平表明神经炎症更大,预后更差.
科学领域:
- 神经免疫学 神经免疫学
- 生物标志物发现发现
- 儿科神经学 儿科神经学
背景情况:
- 抗N-甲基-D-酸盐受体 (NMDAR) 脑炎是一种严重的儿童自身免疫神经系统疾病.
- 准确的诊断和预后生物标志物对于有效管理儿科抗NMDAR脑炎至关重要.
- 在神经细胞表达的溶性触发受体2 (sTREM2) 正在研究其在神经炎症中的作用.
研究的目的:
- 评估在脑脊液 (CSF) 和血清中的可溶性触发受体表达于骨髓细胞2 (sTREM2) 作为儿科抗NMDAR脑炎的诊断和预后生物标志物.
- 评估sTREM2水平与疾病严重程度和结果之间的相关性.
主要方法:
- 这项研究涉及21名患有抗NMDAR脑炎的儿科患者和27名患有非炎症神经障碍 (OND) 的对照患者.
- 用酶相关免疫吸收试验 (ELISA) 分析了CSF和血清样本的sTREM2水平.
- 统计分析包括曼·惠特尼U测试和ROC曲线分析,以确定诊断和预后价值.
主要成果:
- 与对照组相比,患有抗NMDAR脑炎的儿童的CSF和血清sTREM2水平显著更高 (p < 0.001).
- 脑液中sTREM2水平与疾病严重程度 (mRS得分) 有正相关,与神经功能 (GCS得分) 有负相关.
- CSF sTREM2显示出高的诊断准确性 (AUC = 0.887),而血清 sTREM2也显示出显著的准确性 (AUC = 0.848).
- 较低的CSF sTREM2水平与更好的患者预后相关 (p = 0.029).
结论:
- 脑液中sTREM2水平升高与神经炎症增加和儿科抗NMDAR脑炎的不良临床结果有关.
- CSF sTREM2显示出作为诊断儿科抗NMDAR脑炎的有价值生物标志物的潜力.
- sTREM2可以帮助预测预后,并指导受影响儿童的治疗策略.
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