膝关节关节内多核酸对膝关节骨关节炎的真实有效性和安全性:大型多中心观察性研究,重复治疗
Wan-Ho Kim1, Byung-Yoon Sung2, Young-Sun Song3
1Department of Orthopedics, Kim Wan-Ho Orthopedic Clinic, Seoul 07702, Republic of Korea.
Journal of clinical medicine
|February 13, 2026
概括
关节内多核酸 (PN) 对膝关节骨关节炎 (OA) 提供有效的疼痛缓解,与之前的研究相比. 现实世界的数据证实了PNN.
科学领域:
- 整形外科和运动医学
- 再生医学是一种再生医学.
- 临床试验和现实世界的证据.
背景情况:
- 关节内多核酸 (PN) 是膝关节骨关节炎 (OA) 治疗中氨酸 (HA) 的新兴替代品.
- 现有的随机对照试验 (RCT) 表明,PN与HA相比提供了可比或优越的疼痛减轻.
- 在OA患者中,对于单次和重复治疗PN周期的现实世界数据有限.
研究的目的:
- 评估膝关节OA的关节内PN的实际有效性和安全性.
- 在现实环境中比较PN的疼痛减轻与之前PN-HARCT报告的结果.
- 评估重复PN治疗周期的有效性和安全性.
主要方法:
- 对1048名患者的临床数据的回顾性审查,这些患者接受了膝关节OA的关节内PN治疗.
- 疗效分析包括975名每周注射3-5次的患者,在基线,3个月和6个月评估VAS,CGI和PGI.
- 一个由45名患者组成的小组在第一个PN治疗周期6个月后接受了第二次PN治疗周期;在1024名患者中评估了安全性.
主要成果:
- 第一个循环治疗 (n=975) 显示,在6个月内,VAS疼痛显著减少,从50.30mm降至22.43mm (p < 0.0001),与RCT相比较.
- 临床总体印象 (CGI) 和患者总体印象 (PGI) 在6个月后显著改善 (>78%).
- 重复治疗 (n=45) 也显示显著减轻疼痛,达到可比的绝对疼痛水平,没有新的安全问题;仅报告了三起轻度至中度关节痛事件.
结论:
- 关节内PN在现实环境中为膝盖OA患者提供了临床上有意义和持续的疼痛缓解.
- 观察到的疼痛减轻大小与之前PN-HA随机对照试验中报告的可比.
- 重复的PN管理是安全有效的,在不引入新的安全问题的情况下保持好处.
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