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在前列腺癌中,cribriform架构与淋巴血管入侵之间的关联
Jacqueline Chan1, Yetkin Tuac2, Okan Argun1
1Department of Radiation Oncology, Brigham and Women's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Journal of clinical medicine
|February 13, 2026
概括
前列腺癌中的cribriform架构与淋巴血管入侵 (LVI) 密切相关,这表明它表明疾病的早期传播. 这一发现有助于解释cribriform-positive瘤的攻击性行为.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 形结构是前列腺癌中不利的组织病理特征,与糟糕的结果有关.
- 克里布里形阳性瘤可能代表具有早期传播的生物非局部疾病.
- 淋巴血管侵袭 (LVI) 是转移潜力的关键标志物,但其与cribriform形态的关联不清楚.
研究的目的:
- 调查前列腺癌中cribriform形态和LVI之间的关联.
- 为克里布里形阳性前列腺癌的侵袭性临床过程提供生物背景.
主要方法:
- 对338名前列腺腺癌患者进行了彻底前列腺切除术的回顾性分析.
- 对于cribriform架构评估的集中病理学审查.
- 多变量后勤回归来评估cribriform架构与LVI的独立关联,根据格里森得分,瘤阶段和结节状态进行调整.
主要成果:
- 28名 (8.3%) 患者患有LVI,123名 (36.4%) 患者患有cribriform架构.
- 在cribriform阳性瘤 (17.9%) 和cribriform阴性瘤 (2.8%;p < 0.001) 中,LVI的发生率明显高.
- 形结构仍然与LVI独立相关 (调整后OR,5.20;p < 0.001).
结论:
- 形结构与前列腺癌中的LVI有着强烈而独立的关联.
- 这种关联支持cribriform形态和早期转移传播之间的生物学联系.
- 研究结果表明,需要进行前性研究,评估对cribriform-positive前列腺癌的强化治疗.
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