降脂治疗中的治疗惯性:叙述性审查
Marco Vatri1, Andrea Faggiano2, Elisabetta Angelino3
1Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, 50121 Firenze, Italy.
Journal of clinical medicine
|February 13, 2026
概括
治疗惯性,当患有高心血管风险的患者没有及时接受降脂治疗强化时,导致可避免的动脉样硬化负担. 解决这个差距对于预防心血管事件和降低医疗保健成本至关重要.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 降脂治疗中的治疗惯性是心血管医学的一个悖论.
- 大多数高风险患者无法达到指南推的LDL胆固醇目标.
- 证据和实践之间的差距导致了可以避免的动脉样硬化负担.
研究的目的:
- 为了检查二次心血管预防的降脂治疗中的治疗惯性.
- 描述其流行病学,机制和临床后果.
- 提出临床医生表型和可避免的动脉样硬化负担的概念.
主要方法:
- 对当代欧洲和国际数据进行叙述性审查.
- 对医生,患者和系统级惯性决定因素的分析.
- 临床医生表型的特征和可避免的动脉样硬化负担的概念.
主要成果:
- 不到三分之一的二次预防患者达到LDL-C目标.
- 治疗惯性有助于累积血管损伤和心血管事件的增加.
- 临床医生表型和系统层面的因素使惯性延续.
结论:
- 克服治疗惯性是一个临床和伦理的必要条件.
- 预先组合疗法和人工智能等策略可以将脂质管理转变为主动护理.
- 将最佳的脂质管理转化为系统级默认管理是必不可少的.
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