针对侵袭性口腔状细胞癌的光学一致性断层扫描:诊断准确性和与等级和副部位相关的成像特征
Waseem Jerjes1, Zaid Hamdoon2,3, Dara Rashed3
1Faculty of Medicine, Imperial College London, London W12 0BZ, UK.
Journal of clinical medicine
|February 13, 2026
概括
光学连贯断层扫描 (OCT) 可以准确检测口腔状细胞癌 (OSCC),并有助于分类和边缘评估. 这种成像技术有望成为改善口腔癌诊断和治疗规划的宝贵工具.
科学领域:
- 生物医学光学 生物医学光学
- 医学成像医学成像
- 在瘤学瘤学.
背景情况:
- 早期和准确的口腔癌诊断对于患者的治疗结果至关重要.
- 光学连贯断层扫描 (OCT) 提供高分辨率的实时成像,可用于口腔状细胞癌 (OSCC) 诊断和治疗规划.
研究的目的:
- 评估OCT在检测OSCC的诊断性能.
- 评估OCT与瘤等级相关联的成像生物标志物的能力,测量瘤深度,并定义外科手术边缘.
- 调查特定子站点的性能,并确定OSCC的OCT的局限性.
主要方法:
- 一项前性研究,涉及68个OSCC病变和30个相邻的正常粘膜样本的术前OCT扫描.
- 通过对OCT研究结果与组织病理学进行敏感性,特异性和AUC的比较.
- 对OCT生物标志物模式,瘤深度,边缘评估和亚站点性能进行分析.
主要成果:
- 在入侵性OSCC检测中,OCT获得了98.5%的灵敏度和96.7%的特异性 (AUC=0.98).
- 独特的OCT生物标志物模式与瘤分化度相关;深度测量与组织学一致.
- 边缘定义在80%的案例中是准确的,在舌头和口腔底部的表现最高.
结论:
- OCT是一种可重复的实时辅助工具,用于OSCC诊断,边缘规划和病变分层.
- 限制包括光衰减和操作员依赖性;建议使用多中心验证和数字集成.
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