绿色氨酸 (ICG) 光与Tc-99m淋巴细胞切除:优化在皮肤黑色素瘤中哨兵淋巴结检测- 一个系统性审查和元分析
Matteo Matteucci1, Antonio Pesce2, Bruno Cirillo3
1Department of Medicine and General Surgery, University of Milan, 20122 Milan, Italy.
Journal of clinical medicine
|February 13, 2026
概括
印ocyanine绿色 (ICG) 近红外 (NIR) 成像在黑色素瘤分期中识别出更多的哨兵淋巴结 (SLN) 比技术-99m (Tc-99m). 然而,这两种方法在检测转移节点和患者整体结果方面都显示出相似的准确性.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 哨兵淋巴结 (SLN) 活检对于黑色素瘤的分期和治疗决策至关重要.
- 传统的SLN映射使用技术-99m (Tc-99m) 放射性合体.
- 印ocyanine绿色 (ICG) 光成像是SLN活检 (SLNB) 的新兴替代方案.
研究的目的:
- 为了评估ICG近红外 (NIR) 成像的诊断准确性,与SLNB中的Tc-99m淋巴细胞检测相比.
- 为了比较ICG-NIR和Tc-99m方法之间的假阴性率和转移性SLN的检测.
主要方法:
- 进行了对12项研究的系统审查和元分析.
- 主要结果:错误阴性率.
- 二次结局:发现的SLN数量,检测到的转移性SLN数量,以及识别的转移性患者数量.
主要成果:
- ICG发现的SLN明显超过了Tc-99m (OR:0.41).
- 在检测转移节点或ICG和Tc-99m之间的患者之间没有发现显著差异.
- 错误阴性率是可以比较的 (RD:0.03).
结论:
- ICG-NIR成像识别了更多的SLN,但其转移检测率与Tc-99m相比较.
- 对于SLNB来说,ICG-NIR是TC-99m的可靠替代品或辅助.
- 需要进行前性研究来确认ICG的独立诊断作用.
相关概念视频
Detailed Structure and Function of Lymph Nodes
5.1K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
5.1K
Node Analysis for AC Circuits
684
Consider an angioplasty system featuring a catheter equipped with a turbine, a critical tool for removing plaque deposits from coronary arteries. This intricate medical device operates using a circuit model reminiscent of a dual-node RLC circuit powered by a current-controlled voltage source.
To unravel the complexities of this system, nodal analysis is employed, a powerful technique founded on Kirchhoff's current law (KCL), which remains valid for phasors. AC circuits can effectively be...
To unravel the complexities of this system, nodal analysis is employed, a powerful technique founded on Kirchhoff's current law (KCL), which remains valid for phasors. AC circuits can effectively be...
684
Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview
11.6K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.6K
Green Algae
904
Green algae, also referred to as chlorophytes, are different from red algae in having the chloroplasts containing chlorophylls a and b, which give them their distinct green hue. However, they lack phycobiliproteins, preventing them from developing the red or blue-green pigmentation seen in red algae. In terms of photosynthetic pigment composition, green algae closely resemble plants and share a close evolutionary relationship with them. Taxonomically Green algae belong to Phylum Chlorophyta in...
904
Random and Systematic Errors
15.3K
Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
15.3K


