视野进展在童年玻璃眼与开放角度玻璃眼:一个回顾性比较研究
Ainhoa Colina-Jareno1, Ruben Sanchez-Jean1, Irene Serrano-Garcia2
1Ophthalmology Department, Hospital Clinico San Carlos, Institute of Health Research (IdISSC), 28040 Madrid, Spain.
Journal of clinical medicine
|February 13, 2026
概括
儿童绿内障显示视野恶化速度比开角绿内障 (OAG) 慢,进展时间类似. 基线视野状态是两组长期结果的关键预测因素.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 视觉场分析 视觉场分析
背景情况:
- 有限的证据存在于长期视野进展在儿童青光眼与成人开角青光眼 (OAG).
- 了解进展率和预测因素对于有效管理儿科和成人青光眼的关键.
研究的目的:
- 为了比较儿童青光眼和OAG之间视野进展的速度和时间.
- 在这些患者群体中确定最终视野状态的预测因素.
主要方法:
- 171只眼睛的回顾性观察研究 (87个儿童青光眼,84个OAG) 与≥3个视野测试和≥2年的随访.
- 使用章鱼周边测量 (G网格,TOP策略) 评估视觉场;通过平均缺陷 (MD) 率 (dB/年) 评估进展.
- 统计分析包括曼-惠特尼U测试,卡普兰-梅尔,受限平均生存时间 (RMST),考克斯模型和多重线性回归.
主要成果:
- 童年玻璃眼有更糟糕的基线MD和更高的手术率;OAG使用更多的药物.
- 儿童青光眼的中位数MD进展率为-2.3dB/年,而OAG的中位数为0.0dB/年 (p < 0.001),表明儿科病例的恶化速度较慢.
- 无进展生存率和第一次进展的时间在各组之间是相似的;基线MD是最终MD的最强预测因素.
结论:
- 与OAG相比,儿童青光眼的视野恶化似乎较慢,尽管基线状态较差.
- 目前的管理策略可能有助于儿童青光眼的功能稳定.
- 建议进行个性化的随访和及时干预,特别是对于儿科绿眼病患者.
相关概念视频
01:27Open Angle Glaucoma: Treatment
1.0K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.0K
01:28Angle Closure Glaucoma: Treatment
1.3K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.3K
01:25Glaucoma: Overview
1.4K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.4K
01:13Contact Angle
25.7K
When a solid is dipped inside a liquid, the liquid surface becomes curved near the contact. For some solid–liquid interfaces, the liquid is pulled up along the solid, while for others, the liquid surface is convex or depressed near the solid surface. This phenomenon can be explained using the concept of cohesive and adhesive forces.
The adhesive force is the molecular force between molecules of different materials, that is, between the molecules of the solid and the liquid. The cohesive...
The adhesive force is the molecular force between molecules of different materials, that is, between the molecules of the solid and the liquid. The cohesive...
25.7K
01:28Erikson's Theory on Socioemotional Development during Childhood
1.2K
Erik Erikson, a stage theorist, adapted Freud's theory to emphasize social factors in personality development throughout life, a concept known as psychosocial development. Unlike Freud, who focused on early childhood, Erikson believed that personality evolves across eight life stages, each marked by a specific challenge or "crisis." Successful resolution of each stage fosters competence, while failure may lead to feelings of inadequacy.
The first four of Erikson's eight...
The first four of Erikson's eight...
1.2K
02:07Tumor Progression
7.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.5K