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探索炎症性肠病和慢性病之间的联系:全国数据库研究
Chloe Lahoud1, Ali Sohail1, Toni Habib1
1Department of Internal Medicine, Staten Island University Hospital, Northwell Health, New York, NY 10305, USA.
Journal of clinical medicine
|February 13, 2026
概括
炎症性肠病 (IBD) 患者患慢性病 (CKD) 的风险类似,无论他们患有克罗恩病 (CD) 还是性结肠炎 (UC). 然而,死亡率和住院时间等结果在患有CKD的CD和UC患者之间有所不同.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 炎症性肠病 (IBD) 与肠外并发症,特别是病有关.
- 现有的文献表明IBD患者患慢性病 (CKD) 的风险增加.
研究的目的:
- 评估IBD和CKD之间的关联.
- 确定IBD患者中CKD发展的特定风险因素.
- 为了比较克罗恩氏病 (CD) 和性结肠炎 (UC) 之间的CKD患病率和结果.
主要方法:
- 利用了国家住院样本 (NIS) 数据库 (2016-2020) 的数据,用于住院的IBD患者.
- 将患者分层分为克罗恩氏病 (CD) 和性结肠炎 (UC) 队列.
- 进行单变量和多变量分析以确定CKD流行率,危险因素,死亡率和停留时间.
主要成果:
- 鉴定了230,766名IBD患者 (63%CD,37%UC);148,498名患者在1:1匹配后被纳入.
- 在CD和UC患者中,CKD的患病率一致为7.2%.
- 与患有CKD的UC患者相比,患有CD的CKD患者的住院死亡率较低,住院时间较短.
结论:
- 在克罗恩氏病和性结肠炎中,CKD的患病率类似,但风险因素和结果有所不同.
- 患有CKD的CD和UC患者之间存在死亡率和住院时间的显著差异.
- 强调需要针对IBD患者,特别是患有UC的患者进行个性化的CKD风险监测和管理策略.
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