血液培养的可能性正面性使用SeptiCyte RAPID
Krupa A Navalkar1, Alyse Wheelock2, Melissa Gregory2
1Immunexpress Inc., Seattle, WA 98109, USA.
Journal of clinical medicine
|February 13, 2026
概括
塞普赛特快速测试可以帮助预测毒症患者的阳性血液培养. 升高的SeptiScore表明血液感染的可能性更高,有助于临床决策,特别是在资源有限的环境中.
科学领域:
- 临床微生物学 临床微生物学
- 传染病 传染病 传染病
- 诊断测试 诊断测试 诊断测试 诊断测试 诊断测试
背景情况:
- 早期诊断血流感染 (BSI) 和败血症对于有效治疗和改善患者结果至关重要.
- 目前的诊断方法,如血液培养,可能耗时,在资源有限的环境,流行病和军事现场护理中带来挑战.
- 需要工具来指导微生物诊断在重症监护场景的使用.
研究的目的:
- 调查疑似败血症患者的SeptiCyte RAPID测试结果 (SeptiScores) 和血液培养 (BC) 发现之间的关联.
- 为了确定SeptiScores是否可以预测血培阳性的可能性.
主要方法:
- 从北美,欧洲和非洲进行的三项前性临床研究中对个体患者数据进行了后期追溯分析.
- 评估SeptiCyte RAPID测试结果 (SeptiScores) 和血液培养 (BC) 结果之间的相关性.
主要成果:
- 塞普赛特RAPID测试表现出强大的诊断性能,ROC AUC为0.91的BC(+) 与SIRS和0.80的BC(-) 与SIRS.
- 观察到一个显著的正相关性:随着SeptiScore的增加,阳性血液培养的概率也会增加.
- 确定了SeptiScore 10的交叉点,在此点以上,患者具有更高的阳性血液培养的概率.
结论:
- 在血液培养结果之前可获得的升高的SeptiScores,表明血液培养阳性增加.
- SeptiCyte RAPID测试显示,通过潜在地提高血液培养实践的效率,在资源有限的环境中具有临床实用性.
- 这种测试可以帮助患者选择和解释血培结果,以治疗败血症.
相关概念视频
Position-effect Variegation
7.1K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
7.1K
Position and Displacement
27.1K
The position of an object defines its location relative to a convenient frame of reference at any particular time. A frame of reference is an arbitrary set of axes from which the position and motion of an object are described. Earth is often used as a frame of reference, and we often describe the position of an object as it relates to stationary objects on Earth. For example, a rocket launch could be described in terms of the position of the rocket with respect to Earth as a whole. On the other...
27.1K
Serial Position Effect
565
The serial position effect is a cognitive phenomenon where individuals are more likely to recall the first and last items in a list compared to those in the middle. This effect is divided into the primacy effect and the recency effect. The primacy effect is observed when the initial items in a list are remembered better. This occurs because these items are rehearsed more frequently or receive more elaborative processing, allowing them to be encoded into long-term memory more effectively. For...
565
Position Vectors
2.0K
A position vector is a fundamental concept in mathematics that helps determine the position of one point with respect to another point in space. It is a vector that describes the direction and distance between two points. Position vectors are highly useful in the field of math and science, as they help represent spatial relationships and make calculations easier.
For instance, we want to locate a point P(x, y, z) relative to the origin of coordinates O. In that case, we can define a position...
For instance, we want to locate a point P(x, y, z) relative to the origin of coordinates O. In that case, we can define a position...
2.0K
Anatomical Positions
20.6K
In anatomy, several standard anatomical positions are used as references for describing the position and orientation of different body parts. These positions help provide a common frame of reference when discussing anatomical structures. The anatomical position is the standard reference point for describing the body's position and orientation. In this position:
The body is upright, facing forward, and standing erect.
The feet are parallel and flat on the floor.
The arms are hanging by the...
The body is upright, facing forward, and standing erect.
The feet are parallel and flat on the floor.
The arms are hanging by the...
20.6K
Positive, Negative, and Zero Work
22.3K
Work is done on an object when energy is transferred to the object. In other words, work is done when a force acts on a body that undergoes a displacement from one position to another. By definition, the work done by a force is the integral of the force with respect to the displacement along its path. Forces can vary as a function of position, and displacements can occur along various paths between two points. The magnitude of a force multiplied by the cosine of the angle that the force makes...
22.3K


