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Updated: Feb 14, 2026

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眼睛和肠道微生物群轴在了解玻璃眼:一个系统的审查
Bruno Songel-Sanchis1, Laura Morales-Fernández1,2, Javier García-Bardera2
1Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.
Journal of clinical medicine
|February 13, 2026
概括
青光眼患者表现出明显的肠道和眼部微生物变化,与疾病进展和眼睛干燥相关的失生症. 微生物群的分析可能有助于预测和治疗青光眼.
科学领域:
- 眼科医生 眼科 眼科
- 微生物学 微生物学
- 遗传学 是一个遗传学.
背景情况:
- 玻璃眼是不可逆转的失明的主要原因,其特征是视网膜质细胞损失.
- 眼内压升高 (IOP) 是主要的危险因素,但越来越多地认识到微生物群的作用.
- 眼睛和肠道微生物群可能会影响青光眼的发病和进展.
研究的目的:
- 在患有各种青光眼类型的患者中描述眼睛和肠道微生物群.
- 为了研究微生物群组成和青光眼之间的关系.
- 探索失能症,干眼病和青光眼之间潜在的联系.
主要方法:
- 按照PRISMA 2020指南进行系统的文献审查.
- 在2025年6月至9月期间进行的搜索,从121中确定了14个相关的文章.
- 对眼睛和肠道微生物群变化的分析 青光眼患者与对照对照.
主要成果:
- 玻璃眼与影响微生物群的孟德尔遗传倾向有关.
- 甲 (BAK) 治疗增加了格拉姆阴性细菌和脂多糖合成.
- 玻璃眼病患者表现出减少的Corynebacterium乳腺炎和Actinobacteria,并增加了Firmicutes,Proteobacteria和Verrucomicrobiota.
- 在眼睛干燥疾病的玻璃眼患者中,失明症更为严重.
结论:
- 眼睛和肠道微生物群之间存在显著的差异 青光眼的亚型和对照.
- 与年龄相关的失生症和表观遗传因素有助于青光眼的发展.
- 微生物群概况为改善青光眼预测,管理和治疗提供了潜力.
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