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脆弱性中的异质性:生理储备表型和腹部手术后的术后恢复
Rafał Cudnik1, Luigi Marano2,3, Elena Montanari4
1Emergency Department, "Saint Wojciech" Hospital, "Nicolaus Copernicus" Health Center, 80-530 Gdańsk, Poland.
Journal of clinical medicine
|February 13, 2026
概括
术后停留时间 (LOS) 是通过虚弱和肌肉力量更好地预测,而不是按时间表年龄. 将这些措施结合起来,可以识别出具有独特康复模式的患者群体,从而改善手术风险评估.
科学领域:
- 老年学是指老年学的学科.
- 外科手术的结果
- 生理学 生理学 生理学
背景情况:
- 年代年龄是手术患者生物脆弱性的不良指标.
- 虚弱和肌肉力量是生理储备的关键指标.
- 虚弱和肌肉力量对术后停留时间 (LOS) 的综合影响还未得到充分研究.
研究的目的:
- 调查脆弱性和手握强度 (HGS) 对术后LOS的独立和联合影响.
- 探索生理储备表型是否可以改善风险分层,而不是仅仅与年龄相比.
主要方法:
- 对223名接受选择性腹部手术的成年人进行前性多中心观察队列研究.
- 使用弗里德表型评估脆弱性;通过动力计测量HGS.
- 分析长期 (>10天) 和连续的LOS;使用多变量回归模型.
主要成果:
- 虚弱 (OR 3.12) 和瘤手术 (OR 7.63) 独立地预测了长期的LOS; 时间学年龄没有.
- 女性性别与较低的长期LOS几率相关 (或0.39).
- 生理储备表型显示分级的LOS:Fit-Strong患者的停留时间最短,Frail-Weak患者的停留时间最长.
结论:
- 术后的LOS是由多维生理储备决定的,而不仅仅是时间的年龄.
- 整合脆弱性和HGS确定了有意义的表型,以改善外科手术期间风险分层.
- 这种方法可以为个性化的经营期间规划和资源分配提供信息.
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