低剂量RAbeprazole治疗降低高出血风险患者的胃肠道事件 (LORA-HBR):一个前性,多中心,干预性研究
Dong Oh Kang1, Cheol Ung Choi1, Jang Hoon Lee2
1Cardiovascular Center, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul 08308, Republic of Korea.
Journal of clinical medicine
|February 13, 2026
概括
低剂量拉贝普拉在接受抗血栓治疗的高出血风险患者中有效降低了胃肠道并发症. 这种质子抑制剂表现出良好的安全性和高粘附性,表明其在预防胃肠道事件中的实用性.
科学领域:
- 胃肠病学 胃肠病学
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗血栓治疗增加出血风险,特别是在高出血风险 (HBR) 患者中.
- 建议使用质子抑制剂 (PPI) 预防上部胃肠道 (UGI) 出血,但最佳药物和剂量尚不清楚.
- 这项研究评估了低剂量拉贝普拉 (5毫克) 对服用抗血栓剂的HBR患者的GI事件减少.
研究的目的:
- 评估低剂量拉贝普拉在预防胃肠道不良事件方面的疗效和安全性.
- 评估显著的胃肠道事件的发生率,包括出血和胃潰瘍疾病 (PUD).
- 确定特定患者队列中的药物坚持和安全结果.
主要方法:
- 这是一项前性,多中心的干预性研究,涉及909名韩国HBR患者.
- 患者接受了具有HBR特征的长期抗血栓治疗 (例如,年龄≥70,双重抗血小板治疗).
- 主要终点:显著的胃肠道事件的发生率;次要终点:药物停用,心血管事件,死亡率.
主要成果:
- 没有发现显著的UGI出血或症状性PUD.
- 中位坚持率为92.0%;3.52%因胃肠道症状而停止治疗.
- 与胃肠道相关的不良事件发生在3.96%;心血管事件和死亡率较低 (分别为0.33%和0.5%).
结论:
- 低剂量拉贝普拉可显著降低抗血栓治疗的HBR患者的胃肠道并发症.
- 该药物表现出良好的安全性和高患者坚持性.
- 需要进一步的大规模研究来证实这些发现在不同人群中.
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