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Updated: Feb 14, 2026

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1型糖尿病中骨密度和骨质量受损:流行率和关键临床相关性
Simona Zaccaria1,2, Isabella Nardone1,2, Sium Wolde Sellasie1,2
1Division of Endocrinology and Diabetes, CTO Andrea Alesini Hospital, Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.
Journal of clinical medicine
|February 13, 2026
概括
1型糖尿病 (T1DM) 显著影响骨健康,许多成年人患有骨密度下降和微观结构受损. 这些问题与糖尿病持续时间更长,血糖控制较差和慢性并发症有关,强调需要全面评估骨折风险.
科学领域:
- 内分泌学和新陈代谢学
- 骨科和骨健康 骨科和骨健康
- 糖尿病学 糖尿病学
背景情况:
- 1型糖尿病 (T1DM) 与骨质矿物质密度 (BMD) 降低以外的脆弱性骨折风险增加有关.
- 骨质质量受损可能在T1DM相关骨折中发挥关键作用.
- 这项研究调查了T1DM成年人的骨密度和微观架构,看似足够的血糖控制.
研究的目的:
- 确定T1DM成年人骨密度和微观结构变化的患病率.
- 为了确定与这些骨变化相关的临床因素.
- 评估T1DM患者的骨健康状况,尽管血糖控制似乎充足.
主要方法:
- 这是一项对68名患有T1DM的成年人 (18-69岁) 的横截面研究.
- 骨矿物质密度 (BMD) 通过DXA进行评估;骨微架构使用椎骨分数 (TBS) 进行评估.
- 收集了临床,代谢 (HbA1c) 和生活方式 (身体活动 - PA) 数据.
主要成果:
- 在35.3%的患者中发现减少的BMD;在45.6%的患者中发现改变的TBS.
- 减少的BMD和改变的TBS都与年龄较大,糖尿病持续时间较长,血压较低和微血管并发症 (神经病变,视网膜病变) 相相关.
- 较高的HbA1c和心血管风险因素与改变的TBS有关;多变量分析将老年和较高的HbA1c与减少的TBS联系起来,中度高的PA与更好的骨微架构联系起来.
结论:
- 在T1DM成年人中,骨密度和质量受损是常见的,与疾病持续时间,代谢控制和并发症有关.
- 联合评估BMD和TBS可能会改善T1DM中骨折风险评估.
- 专注于预防糖尿病并发症和促进健康生活方式的战略至关重要.
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