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谷物沉积物调节肠道微生物群-代谢轴与Apoe小鼠的高脂血相关
Wenhui Duan1,2, Qijie Guan3, Yilin Ren2
1Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, State Key Laboratory of Food Science and Resources, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Foods (Basel, Switzerland)
|February 13, 2026
概括
谷物沉积物 (CVS) 对超脂症小鼠的肠道微生物群和代谢物产生影响. 虽然血清脂质的改善是有限的,但CVS重塑了肠道细菌和代谢途径,这表明它在管理高脂血症方面发挥了作用.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 营养科学 营养科学
背景情况:
- 谷物沉积物 (CVS) 是一种传统的发酵副产品,被认为具有健康益处.
- CVS对遗传诱导的高脂血症的具体影响尚不清楚.
- 缺乏阿波脂蛋白-E (Apoe-/-) 的小鼠是研究高脂血症的标准模型.
研究的目的:
- 研究两种类型的CVS (Dade-CVS和Hengshun-CVS) 对高脂血症Apoe-/-小鼠的影响.
- 分析CVS对血清参数,肠道微生物组成和代谢途径的影响.
- 探索肠道微生物群,代谢物和脂质资料之间的关系.
主要方法:
- 用达德-CVS (DD-CVS) 和恒顺-CVS (HS-CVS) 治疗阿波-/-小鼠.
- 血清生物化学参数的分析.
- 16S rRNA基因测序用于肠道微生物社区概况.
- 使用基因和基因组京都百科全书 (KEGG) 正义 (KO) 数据预测代谢途径.
- 没有针对性的代谢分析.
- 微生物,代谢和血清数据之间的相关性分析.
主要成果:
- 无论是DD-CVS还是HS-CVS,在某些血清参数中都显示出有限但显著的改善.
- 治疗CVS显著改变了肠道微生物群落,DD-CVS增加了Dubosiella和减少了Desulfovibrio,而HS-CVS影响了Bifidobacterium和Akkermansia.
- 预测的代谢途径不同:DD-CVS与维生素,氨基酸和能量代谢有关,而HS-CVS与胆酸生物合成和能量途径有关.
- 代谢分析发现了N1-乙精氨酸,酸和25-胆固醇等代谢物的显著变化.
- 相关性分析揭示了特定肠道细菌 (Alistipes,Enterorhabdus,Romboutsia),代谢物和血清脂质指标之间的关联.
结论:
- 在超脂症小鼠中,谷物沉积物主要调节肠道微生物群-代谢物轴.
- 通过对肠道微生物群及其相关代谢途径的影响,CVS具有部分脂质调节作用.
- 这些发现为了解CVS在高脂血症背景下的功能益处提供了基础.
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